What is the distance between St. Louis and Buffalo?

The distance between the two cities is 660 miles (1065 km).

What are the departure and arrival stations when taking the bus from St. Louis to Buffalo?

If you're headed to Buffalo from St. Louis, chances are that your bus will depart from Gateway Station and arrive at Buffalo Airport. These are the primary departure and arrival locations on this route, there are other pick-up and drop-off locations that could make it easier for you to reach your destination.

Bus St. Louis to Buffalo from $95 | Refundable Tickets

Previously seen trips

Next departures for St. Louis to Buffalo on November 23
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
	Bus	1:45pm	Gateway Station	1d 1h	4:15pm	Buffalo, NY (181 Ellicott St, Buffalo, NY 14203, United States)	No tags
FlixBus + Greyhound	Bus	1:30pm	Gateway Station	1d 7h	10:25pm	Buffalo (BUF) Airport	No tags
	Bus	1:45pm	Gateway Station	1d 1h	4:15pm	Buffalo, NY (181 Ellicott St, Buffalo, NY 14203, United States)	No tags
Greyhound + FlixBus	Bus	12:50am	Gateway Station	1d 14h	4:10pm	Buffalo (BUF) Airport	No tags
Greyhound + FlixBus	Bus	1:30pm	Gateway Station	1d 7h	10:25pm	Buffalo (BUF) Airport	No tags

Compare 2 ways to go from St. Louis to Buffalo

We recommend taking the train

Among the sustainable travel choices, the train stands out as the good way to reach Buffalo. The journey takes about 16 hours 58 minutes and with fares starting at just $126, it presents an excellent value for a comfortable ride.

2train per day

16h 58mAverage Duration

668 milesDistance

98kgCO₂ emissions

	Average Price	Average Duration	CO₂ emissions	Actions
Bus	Average Price$75 - $254	Average Duration1d 8h	CO₂ emissions 27kg CO₂e
Train	Average Price$126 - $962	Average Duration16h 58m	CO₂ emissions 98kg CO₂e

Where are the popular stops in St. Louis and Buffalo?

Stops in St. Louis

A
Gateway Station
430 S 15th St, St Louis, MO 63103
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Stops in Buffalo

A
Buffalo Airport
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B
Transportation Center
185 Ellicott St, Buffalo, NY 14203, USA
Visit page
C
Exchange Street Station
75 Exchange St, Buffalo, NY 14203, USA
Visit page

Compare bus companies

Greyhound

3.5/587,391 reviews

Staff3.6

Timeliness2.9

Cleanliness3.3

Wifi2.4

Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.

US bus companies: FlixBus, BlaBlaCar Bus, ALSA, Greyhound, Intercape, Trenitalia, Sindbad

Frequently asked questions about traveling from St. Louis to Buffalo, NY by bus

What is the distance between St. Louis and Buffalo?
What are the departure and arrival stations when taking the bus from St. Louis to Buffalo?

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

11/21

No data

11/22

No data

Today

No data

11/24

No data

11/25

$134

11/26

No data

11/27

No data

11/28

$155

The cheapest trip from St. Louis to Buffalo, NY was searched and found on Nov 25, 2025 with a price of $134

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from St. Louis to Buffalo, NY, as early as possible.

You can expect to pay from $134 to $155 for a bus ticket from St. Louis to Buffalo, NY based on the last 2 days. You can expect to find the cheapest price for the trip at $134 which is on 2025-11-25.