Bus Tickets from St. Louis to Knoxville, TN

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TodayJul 22
TomorrowJul 23
from $115
ThuJul 24
FriJul 25
SatJul 26
from $125
SunJul 27
MonJul 28
from $106
TueJul 29

Cheap buses leaving tomorrow

One passenger / one way

  • This trip is recommended because it is: Cheapest
    Departure time: July 23 at
    Departure city: St. Louis
    Departure location: Gateway Station
    Arrival time: July 23 at
    Destination city: Knoxville
    Destination location: Knoxville Bus Station
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • This trip is recommended because it is: Fastest
    Departure time: July 23 at
    Departure city: St. Louis
    Departure location: Gateway Station
    Arrival time: July 23 at
    Destination city: Knoxville
    Destination location: Knoxville Bus Station
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: July 23 at
    Departure city: St. Louis
    Departure location: Gateway Station
    Arrival time: July 23 at
    Destination city: Knoxville
    Destination location: Knoxville Bus Station
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: July 23 at
    Departure city: St. Louis
    Departure location: Gateway Station
    Arrival time: July 23 at
    Destination city: Knoxville
    Destination location: Knoxville Bus Station
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: July 23 at
    Departure city: St. Louis
    Departure location: Gateway Station
    Arrival time: July 24 at
    Destination city: Knoxville
    Destination location: Knoxville Bus Station
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:

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Bus St. Louis to Knoxville, TN: Trip Overview

Average ticket price$115
Average bus trip duration15h 45m
Number of daily buses3
Earliest bus departure2:30am
Distance392 miles (631 km)
Latest bus departure11:30pm

St. Louis to Knoxville Bus

Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from St. Louis to Knoxville.

We make it our job to connect you with the most dependable bus companies that cover bus service from St. Louis to Knoxville.

Whether it is cheap bus tickets or more luxurious buses going to Knoxville from St. Louis, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions for your trip St. Louis - Knoxville, TN

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
07/20
$179
07/21
$110
Today
No data
07/23
$107
07/24
No data
07/25
No data
07/26
$117
07/27
No data
busbud logoThe cheapest trip from St. Louis to Knoxville, TN was searched and found on Jul 23, 2025 with a price of $107

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from St. Louis to Knoxville, TN, as early as possible.

You can expect to pay from $107 to $236 for a bus ticket from St. Louis to Knoxville, TN based on the last 2 days. You can expect to find the cheapest price for the trip at $107 which is on 2025-07-23.

About Bus Travel

Bus Travel Tips

If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from St. Louis to Knoxville but it'll also be endearing to native speakers who will surely appreciate your effort.

From miles long of beauteous natural landscapes to impressive man-crafted sights, you're bound to be in for a visual treat on your bus trip from St. Louis to Knoxville.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from St. Louis to Knoxville.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from St. Louis to Knoxville.

Did you know?

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.

9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

Will you be returning to St. Louis by bus?

Bus from St. Louis to Knoxville, TN

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