Bus Tickets from St. Louis to Knoxville, TN

Previously seen trips

Next departures for St. Louis to Knoxville on October 12
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Greyhound
Gateway Station
Knoxville Bus StationNo tags
Greyhound
Gateway Station
Knoxville Bus StationNo tags
Greyhound
Gateway Station
Knoxville Bus StationNo tags
Greyhound
Gateway Station
Knoxville Bus StationNo tags
Greyhound
Gateway Station
Knoxville Bus StationNo tags

Accepted payments

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  • China Union Pay
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Bus St. Louis to Knoxville, TN: Trip Overview

Average ticket price$79
Average bus trip duration16h 15m
Number of daily buses2
Earliest bus departure2:00am
Distance392 miles (631 km)
Latest bus departure11:30pm

St. Louis to Knoxville Bus

Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from St. Louis to Knoxville.

We make it our job to connect you with the most dependable bus companies that cover bus service from St. Louis to Knoxville.

Whether it is cheap bus tickets or more luxurious buses going to Knoxville from St. Louis, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions for your trip St. Louis - Knoxville, TN

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
10/09
$117
10/10
$155
Today
No data
10/12
$124
10/13
No data
10/14
$75
10/15
No data
10/16
No data
busbud logoThe cheapest trip from St. Louis to Knoxville, TN was searched and found on Oct 14, 2025 with a price of $75

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from St. Louis to Knoxville, TN, as early as possible.

You can expect to pay from $75 to $155 for a bus ticket from St. Louis to Knoxville, TN based on the last 2 days. You can expect to find the cheapest price for the trip at $75 which is on 2025-10-14.

About Bus Travel

Bus Travel Tips

If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from St. Louis to Knoxville but it'll also be endearing to native speakers who will surely appreciate your effort.

From miles long of beauteous natural landscapes to impressive man-crafted sights, you're bound to be in for a visual treat on your bus trip from St. Louis to Knoxville.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from St. Louis to Knoxville.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from St. Louis to Knoxville.

Did you know?

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.

9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

Will you be returning to St. Louis by bus?

Bus from Knoxville, TN to St. Louis

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