Find coaches from St. Louis to Knoxville, TN

Next departures

Next departures from St. Louis to Knoxville on 12 October
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Greyhound Lines, Inc.
Gateway Station
Knoxville Bus StationCheapestFastest
FlixBus + Greyhound Lines, Inc.
Gateway Station
Knoxville Bus StationNo tags

Last refresh of the prices: Today at 02:46 CDT.

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Bus St. Louis to Knoxville, TN: Trip Overview

Average ticket priceUS$79
Average bus trip duration16h 15m
Number of daily buses2
Earliest bus departure02:00
Distance392 miles
Latest bus departure23:30

St. Louis to Knoxville Bus

Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from St. Louis to Knoxville.

We make it our job to connect you with the most dependable bus companies that cover bus service from St. Louis to Knoxville.

Whether it is cheap bus tickets or more luxurious buses going to Knoxville from St. Louis, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions on the trip St. Louis - Knoxville, TN

  1. How far is Knoxville from St. Louis by coach?

    The journey from St. Louis to Knoxville by coach covers an approximate distance of 391 miles (630 km).

  2. Is there a way to reach Knoxville from St. Louis without flying?

    To travel from St. Louis to Knoxville without flying, you can take the coaches. The coach ensures a pleasant travel experience, granting you the opportunity to appreciate the scenery as you make your way to your final stop. You also have the option of utilising carpooling services.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
09/10
US$117
10/10
US$155
Today
No data
12/10
US$124
13/10
No data
14/10
US$75
15/10
No data
16/10
No data
busbud logoThe cheapest trip from St. Louis to Knoxville, TN was searched and found on 14 Oct 2025 with a price of US$75

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from St. Louis to Knoxville, TN as early as possible.

You can expect to pay from US$75 to US$155 for a bus ticket from St. Louis to Knoxville, TN based on the last 2 days. You can expect to find the cheapest price for the trip at US$75, which is on 2025-10-14.

About Bus Travel

Bus Travel Tips

If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from St. Louis to Knoxville but it'll also be endearing to native speakers who will surely appreciate your effort.

From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from St. Louis to Knoxville.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from St. Louis to Knoxville.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from St. Louis to Knoxville.

Did you know?

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.

9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

Will you be returning to St. Louis by bus?

Bus from Knoxville, TN to St. Louis

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