Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound Lines, Inc. + FlixBus | Bus | Tallahassee (CK Steele Bus Plaza) | Key West Bus Station | Cheapest | ||||
 | Bus | Tallahassee (CK Steele Bus Plaza) | Key West Bus Station | Fastest |
Last refresh of the prices: Last Saturday at 11:42 PM EST.
Get from Tallahassee to Key West
The journey takes about 18 hours 25 minutes and with fares starting at just $133, it presents an excellent value for a comfortable ride.
Where are the popular stops in Tallahassee and Key West?
Stops in Tallahassee
- A32670 Blue Star Hwy, Midway, FL 32343, USA
- B1021 St Augustine St, Tallahassee, FL 32304, USA
- C329 Marriott Dr, Tallahassee, FL 32301
- D112 W Tennessee St, Tallahassee, FL 32301
Stops in Key West
- A908 Caroline St, Key West, FL 33040, USA
- B
EYW Airport
3535 Florida A1A, Key West, FL 33040, USA
Compare bus companies
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Frequently asked questions about traveling from Tallahassee to Key West by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Tallahassee to Key West?
The cheapest bus tickets from Tallahassee to Key West start from $133. The average price for this route is around $147. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Tallahassee to Key West?
The average bus trip duration from Tallahassee to Key West is 18h 25m, covering a distance of 435 miles (701 km). The quickest bus can get you there in 18h 25m and is operated by Greyhound.
Which bus companies service the Tallahassee to Key West route?
Several major train operators operate on this route with 2 trains available per day.
What is the earliest and latest departure time for the bus from Tallahassee to Key West?
The earliest bus departs from Tallahassee to Key West at 11:25am. And the latest bus departs at 9:05pm.
What are the CO₂ emissions for the bus trip from Tallahassee to Key West?
A bus trip from Tallahassee to Key West generates an estimated 18 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Tallahassee to Key West was searched and found on Dec 15, 2025 with a price of $137To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Tallahassee to Key West, as early as possible.
You can expect to pay from $137 to $165 for a bus ticket from Tallahassee to Key West based on the last 2 days. You can expect to find the cheapest price for the trip at $137 which is on 2025-12-16.
Top traveled bus routes
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Popular bus departures from Tallahassee
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