Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Greyhound Orlando Key West recent customer reviews
Overall very unhappy with this trip. Bus was 2 hours late, staff on the bus, driver was courteous but the other “helper” was rude and no help at all. I asked him for options or ideas so I could make it down to Key West on time for an appointment and he couldn’t be bothered, even though he was just sitting in the front doing nothing.
Because the bus was 2 hours late getting to Miami, I missed my bus to Key West. The staff at Miami was extremely slow and I found a shuttle in the meantime to take me there instead so I could make my appointment.
Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.
Jet Set Express Terminal, 3718 LB Mcleod Rd., 32805 Orlando, FL,, United StatesJet Set Express Terminal
D - Disney World
Disney's All-Star Sports Resort, 1701 West Buena Vista Dr., Orlando, FL 32830
E - International Dr SuperTours Terminal
5419 International Dr, Orlando, FL 32819, USA
F - Seaworld Hotels
10100 International Drive , Orlando, 32821
Stops in Key West
A - Caroline St
908 Caroline St, Key West, FL 33040, USACaroline St
B - EYW Airport
3535 Florida A1A, Key West, FL 33040, USA
Frequently asked questions about traveling from Orlando to Key West by bus
How far is Orlando from Key West?
The distance between the two cities is 276 miles (445 km).
What are the departure and arrival stations when taking the bus from Orlando to Key West?
Most of the buses traveling from Orlando to Key West leave from Orlando Bus Station and arrive at Caroline St. These are the main departure and arrival locations on this route, but you can find others that could fit better into your travel plans.
What are the best sights and things to do in Key West?
Once in Key West, you can start exploring the city and discover its surroundings. The top sights and things to do are Key West Shipwreck Museum, Duval street, Mallory Square, Florida Keys Eco-Discovery Center and The Vandenberg Wreck.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
11/17
$75
11/18
$85
Today
$78
11/20
$80
11/21
No data
11/22
No data
11/23
No data
11/24
$67
The cheapest trip from Orlando to Key West was searched and found on Nov 24, 2025 with a price of $67
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Orlando to Key West, as early as possible.
You can expect to pay from $67 to $85 for a bus ticket from Orlando to Key West based on the last 2 days. You can expect to find the cheapest price for the trip at $67 which is on 2025-11-24.
The cheapest trip from Orlando to Key West was searched and found on Nov 24, 2025 with a price of $67
