Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Greyhound Lines, Inc. Tampa Panama City recent customer reviews
enjoy the driver, but the unpleasant smell from the restroom affects the atmosphere of the bus. please install something into rest to prevent the bad smell.
Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.
Frequently asked questions about traveling from Tampa to Panama City, US by bus
What is the travel distance from Tampa to Panama City?
Tampa and Panama City are 247 miles (398 km) apart.
What are the departure and arrival stations when taking the bus from Tampa to Panama City?
The majority of buses traveling from Tampa to Panama City start their journey at Tampa 13th Avenue Bus Stop (McDonald's) and wind up at Panama City Greyhound Bus Station. These are the most popular pick-up and drop-off locations on this route, but you could find others that could be a better fit for your travel plans.
What are the best sights and things to do in Panama City?
Once in Panama City, you can start exploring the city and discover its surroundings. The top sights and things to do are The Panama Canal, Jungle Land Panama, The Fish Market, Bird Watching and Museo Antropologico Reina Torres De Arauz.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
11/19
$77
11/20
$79
Today
$73
11/22
No data
11/23
$75
11/24
$73
11/25
No data
11/26
No data
The cheapest trip from Tampa to Panama City, US was searched and found on Nov 21, 2025 with a price of $73
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Tampa to Panama City, US, as early as possible.
You can expect to pay from $73 to $79 for a bus ticket from Tampa to Panama City, US based on the last 2 days. You can expect to find the cheapest price for the trip at $73 which is on 2025-11-24.
The cheapest trip from Tampa to Panama City, US was searched and found on Nov 21, 2025 with a price of $73
