Bus Tickets from Winston-Salem to St. Louis

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TodayAug 31
TomorrowSep 1
from $116
TueSep 2
WedSep 3
ThuSep 4
FriSep 5
SatSep 6
SunSep 7

Cheap buses leaving tomorrow

One passenger / one way

  • This trip is recommended because it is: Cheapest
    Departure time: September 1 at
    Departure city: Winston-Salem
    Departure location: Winston Salem Greyhound Bus Station
    Arrival time: September 2 at
    Destination city: St. Louis
    Destination location: Gateway Station
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:
  • This trip is recommended because it is: Fastest
    Departure time: September 1 at
    Departure city: Winston-Salem
    Departure location: Winston Salem Greyhound Bus Station
    Arrival time: September 2 at
    Destination city: St. Louis
    Destination location: Gateway Station
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: September 1 at
    Departure city: Winston-Salem
    Departure location: Winston Salem Greyhound Bus Station
    Arrival time: September 2 at
    Destination city: St. Louis
    Destination location: Gateway Station
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:
  • Departure time: September 1 at
    Departure city: Winston-Salem
    Departure location: Winston Salem Greyhound Bus Station
    Arrival time: September 2 at
    Destination city: St. Louis
    Destination location: Gateway Station
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:

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Bus Winston-Salem to St. Louis: Trip Overview

Average ticket price$108
Average bus trip duration1d
Number of daily buses3
Earliest bus departure10:20am
Distance573 miles (923 km)
Latest bus departure6:15pm

Winston-Salem to St. Louis Bus

Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from Winston-Salem to St. Louis.

We make sure you can find a bus service from Winston-Salem to St. Louis from the most reliable bus companies operating this trip.

Whether it is cheap bus tickets or more luxurious buses going to St. Louis from Winston-Salem, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions for your trip Winston-Salem - St. Louis

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
08/29
$86
08/30
$82
Today
No data
09/01
$108
09/02
No data
09/03
No data
09/04
No data
09/05
No data
busbud logoThe cheapest trip from Winston-Salem to St. Louis was searched and found on Aug 30, 2025 with a price of $82

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Winston-Salem to St. Louis, as early as possible.

You can expect to pay from $82 to $108 for a bus ticket from Winston-Salem to St. Louis based on the last 2 days. You can expect to find the cheapest price for the trip at $108 which is on 2025-09-01.

About Bus Travel

Bus Travel Tips

If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from Winston-Salem to St. Louis but it'll also be endearing to native speakers who will surely appreciate your effort.

Start sightseeing the minute your bus leaves the station. If you're on the night bus from Winston-Salem to St. Louis, get comfy and count the stars.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Winston-Salem to St. Louis.

Make a music playlist for your bus ride from Winston-Salem to St. Louis, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

Will you be returning to Winston-Salem by bus?

Bus from St. Louis to Winston-Salem

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