Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound Lines, Inc. + FlixBus | Bus | Midway Truck Plaza Bus Stop | Downtown Greyhound Station | Cheapest | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Midway Truck Plaza Bus Stop | Chicago 95Th & Dan Ryan | Fastest | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Midway Truck Plaza Bus Stop | Downtown Greyhound Station | No tags | ||||
 | Bus | Midway Truck Plaza Bus Stop | 537-517 W. Jackson Blvd | No tags | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Columbia Wabash Station | Downtown Greyhound Station | No tags |
Last refresh of the prices: Last Sunday at 4:20 PM CST.
Get from Columbia to Chicago
The journey takes about 11 hours 35 minutes, and with fares starting at just $79, it presents an excellent value for a comfortable ride.
Compare bus companies
Based on 87382 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the WiFi. Greyhound ticket prices on this trip start at $79
Greyhound Columbia Chicago recent customer reviews
I will never rude it again I had to call off work this morning because I had 3 delays on my busses which is very sad
Shekena W.
Bus was wery dirty
Magdalena C.
I waited at a transfer for 3 hours because nobody could find a driver
Nikole G.
Where are the popular stops in Columbia and Chicago?
Frequently asked questions about travelling from Columbia, MO to Chicago by bus
What is the travel distance from Columbia to Chicago?
The distance covered from Columbia to Chicago is 512 km (318 miles).
What are the departure and arrival locations for buses traveling from Columbia to Chicago?
Buses traveling this route start their trip at Midway Truck Plaza Bus Stop, in Columbia, and end it at Downtown Greyhound Station, in Chicago.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Columbia, MO to Chicago was searched and found on Nov 19, 2025 with a price of $83To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Columbia, MO to Chicago, as early as possible.
You can expect to pay from $83 to $143 for a bus ticket from Columbia, MO to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at $96 which is on 2025-11-22.
