Previously seen trips
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Bus station | Harrisburg Bus Station | No tags | ||||
| Bus | Bus station | Harrisburg Bus Station | No tags | ||||
Greyhound + FlixBus | Bus | Florence, SC | Harrisburg Bus Station | No tags | ||||
FlixBus + Greyhound | Bus | Florence, SC | Harrisburg Bus Station | No tags | ||||
FlixBus + Greyhound | Bus | Florence, SC | Harrisburg Bus Station | No tags |
Compare 2 ways to go from Florence to Harrisburg
Among the sustainable travel choices, the train stands out as a good way to reach Harrisburg. The journey takes about 13 hours 15 minutes, and with fares starting at just $251, it presents an excellent value for a comfortable ride.
Where are the popular stops in Florence and Harrisburg?
Stops in Florence
- A619 S Irby St, Florence, SC 29501, USA
- B
TA Travel Center - Florence
2301 W Lucas St, Florence, SC 29501, USA
Stops in Harrisburg
- A
Harrisburg Bieber Greyhound Station
411 Market St, Harrisburg, PA 17101
Compare bus companies
Frequently asked questions about travelling from Florence, SC, US to Harrisburg by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Florence to Harrisburg?
The cheapest bus tickets from Florence to Harrisburg start from $171. The average price for this route is around $235. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Florence to Harrisburg?
The average bus travel time from Florence to Harrisburg is 21h 25m, covering a distance of 722 km. The quickest bus can get you there in 21h 25m and is operated by Greyhound.
Which bus companies service the Florence to Harrisburg route?
What are the earliest and latest departure times for the bus from Florence to Harrisburg?
The earliest bus departs from Florence to Harrisburg at 12:05am. And the latest bus departs at 4:30pm.
What are the CO₂ emissions for the bus trip from Florence to Harrisburg?
A bus trip from Florence to Harrisburg generates an estimated 18 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
What is the best bus company from Florence to Harrisburg?
According to Busbud customers, the highest-rated bus company on this route is Greyhound, with an average rating of 3.5 out of 5 stars based on 87435 reviews.
Which bus company has the best Wi-Fi from Florence to Harrisburg?
Based on Busbud reviews, the bus company FlixBus has the highest Wi-Fi rating with a score of 2.7.
Which bus company has the best on-time performance from Florence to Harrisburg?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Florence to Harrisburg?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Florence, SC, US to Harrisburg was searched and found on Dec 30, 2025 with a price of $236To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Florence, SC, US to Harrisburg, as early as possible.
What's the cheapest way to go from Florence, SC, US to Harrisburg?
The bus is the cheapest travel choice for this destination
