Bus Tickets from Florence, SC, US to Harrisburg

Previously seen trips

Next departures for Florence to Harrisburg on November 3
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Greyhound
    		Bus station
    		Harrisburg Bus StationNo tags
    FlixBus + Greyhound
      		Florence, SC
      		Harrisburg Bus StationNo tags
      Greyhound + FlixBus
        		Florence, SC
        		Harrisburg Bus StationNo tags
        Greyhound
          		Bus station
          		Harrisburg Bus StationNo tags
          FlixBus + Greyhound
            		Florence, SC
            		Harrisburg Bus StationNo tags

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            Compare 2 ways to go from Florence to Harrisburg

            We recommend taking the train

            Among the sustainable travel choices, the train stands out as a good way to reach Harrisburg. The journey takes about 13 hours 15 minutes, and with fares starting at just US$172, it presents an excellent value for a comfortable ride.

            2train per day
            13h 15mAverage Duration
            721 kmDistance
            66kgCO₂ emissions
            Bus
            		Average PriceUS$83 - US$279Average Duration20h 55m
            18kg CO₂e
            Train
            		Average PriceUS$172 - US$244Average Duration13h 15m
            66kg CO₂e

            Bus Florence, SC, US to Harrisburg: Trip Overview

            Average Ticket PriceUS$165
            Average Bus Trip Duration20h 55m
            Number of daily buses1
            Earliest bus departure12:05am
            Distance721 km
            Latest bus departure4:15pm

            Florence to Harrisburg Bus

            Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from Florence to Harrisburg.

            We make sure you can find a bus service from Florence to Harrisburg from the most reliable bus companies operating this trip.

            Whether it is cheap bus tickets or more luxurious buses going to Harrisburg from Florence, we help you find what you're looking for based on how much of a budget you have.

            Frequently asked questions on the trip Florence, SC, US - Harrisburg

            1. What is the distance between Florence and Harrisburg?

              It's about 718 km (446 miles) from Florence to Harrisburg.

            2. What are the departure and arrival locations for buses traveling from Florence to Harrisburg?

              Buses departing from Florence Bus Station in Florence will take you to Harrisburg Bieber Greyhound Station in Harrisburg.

            Find cheapest prices for buses

            Price is for a one-way ticket for one passenger and based on past searches.

            Best price found
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            US$94
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            busbud logoThe cheapest trip from Florence, SC, US to Harrisburg was searched and found on Nov 3, 2025 with a price of US$94

            To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Florence, SC, US to Harrisburg, as early as possible.

            About Bus Travel

            Bus Travel Tips

            If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from Florence to Harrisburg but it'll also be endearing to native speakers who will surely appreciate your effort.

            Start sightseeing the minute your bus leaves the station. If you're on the night bus from Florence to Harrisburg, get comfy and count the stars.

            Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Florence to Harrisburg.

            Tune out to the fine sounds of your best music playlist on your bus trip from Florence to Harrisburg while indulging in miles on end of beautiful scenic views.

            Did you know?

            9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

            Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travellers have used their electronic device on board during 2014.

            The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

            What's the cheapest way to go from Florence, SC, US to Harrisburg?

            busbud logoThe bus is the cheapest travel choice for this destination

            Will you be returning to Florence, SC, US by bus?

            Bus from Harrisburg to Florence, SC, US

            You can also go to Harrisburg by train

            Train from Florence, SC, US to Harrisburg

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