Previously seen trips

Next departures for Florence to Harrisburg on October 15
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location
Greyhound + FlixBus	Bus Wifi Toilet Power outlets	12:05am	Florence, SC	14h 50m	2:55pm	Harrisburg Bus Station
FlixBus + Greyhound	Bus Wifi Toilet Power outlets	12:05am	Florence, SC	13h 50m	1:55pm	Harrisburg Bus Station
FlixBus + Greyhound	Bus Wifi Toilet Power outlets	4:15pm	Bus station	20h 55m	1:10pm	Harrisburg Bus Station
	Bus Wifi Toilet Power outlets	4:15pm	Bus station	22h 20m	2:35pm	Harrisburg
Greyhound + FlixBus	Bus Wifi Toilet Power outlets	12:05am	Florence, SC	13h 50m	1:55pm	Harrisburg Bus Station

Compare 2 ways to go from Florence to Harrisburg

We recommend taking the train

Among the sustainable travel choices, the Train stands out as a good way to reach Harrisburg. The journey takes about 14 hours 15 minutes and with fares starting at just $188, it presents an excellent value for a comfortable ride.

2train per day

14h 15mAverage Duration

447 milesDistance

66kgCO₂ emissions

	Average Price	Average Duration	CO₂ emissions	Actions
Bus	Average Price$126 - $234	Average Duration18h 35m	CO₂ emissions 18kg CO₂e
Train	Average Price$188 - $258	Average Duration14h 15m	CO₂ emissions 66kg CO₂e

Bus stations and stops in Florence and Harrisburg

Stops in Florence

A
Florence Bus Station
619 S Irby St, Florence, SC 29501, USA
Visit page
B
TA Travel Center - Florence
2301 W Lucas St, Florence, SC 29501, USA

Stops in Harrisburg

A
Harrisburg Bieber Greyhound Station
411 Market St, Harrisburg, PA 17101

Compare bus companies

Greyhound

3.5/588,231 reviews

Staff3.6

Timeliness3.0

Cleanliness3.4

Wifi2.5

Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.

FlixBus

3.5/516,244 reviews

Staff4.2

Timeliness4.0

Cleanliness4.1

Wifi2.7

Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.

US bus companies:FlixBus, Greyhound, Tufesa, Chihuahuenses, Adirondack Trailways, Valley Transit, Wanda Coach

Frequently asked questions about traveling from Florence, SC, US to Harrisburg by bus

Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.

How much is the bus ticket from Florence to Harrisburg?
The cheapest bus tickets from Florence to Harrisburg start from $126. The average price for this route is around $169. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Florence to Harrisburg?
The average bus trip duration from Florence to Harrisburg is 18h 35m, covering a distance of 448 miles (722 km). The quickest bus can get you there in 19h 50m and is operated by Greyhound.
Which bus companies service the Florence to Harrisburg route?
Several major bus companies operate on this route with 3 buses available per day, including services from Greyhound, FlixBus.
What is the earliest and latest departure time for the bus from Florence to Harrisburg?
The earliest bus departs from Florence to Harrisburg at 12:05am. And the latest bus departs at 7:20pm.
What are the CO₂ emissions for the bus trip from Florence to Harrisburg?
A bus trip from Florence to Harrisburg generates an estimated 18.044974999999997 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
What is the best bus company from Florence to Harrisburg?
According to Busbud customers, the highest-rated bus company on this route is Greyhound, with an average rating of 3.5 out of 5 stars based on 88213 reviews.
Which bus company has the best Wi-Fi from Florence to Harrisburg?
Based on reviews on Busbud, the bus company FlixBus has the best Wi-Fi rating with a score of 2.7.
Which bus company has the most timely service from Florence to Harrisburg?
According to Busbud traveler reviews, the most timely bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Florence to Harrisburg?
According to Busbud traveler reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.