Next departures for Lyon to Brussels on November 20
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Perrache
Brussels North Train Station
Cheapest
Bus
Perrache
Brussels South (Gare du Midi)
Fastest
Bus
Aéroport LYS
Brussels North Train Station
No tags
Bus
Aéroport LYS
Brussels North Train Station
No tags
Bus
Aéroport LYS
Brussels North Train Station
No tags
Next departures for Lyon to Brussels on November 21
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Perrache
Brussels South (Gare du Midi)
Cheapest
Bus
Perrache
Brussels South (Gare du Midi)
Fastest
Bus
Lyon - Perrache Bus Station
Brussels-South (Gare du Midi)
No tags
Bus
Aéroport LYS
Brussels North Train Station
No tags
Bus
Lyon - Perrache Bus Station
Brussels-South (Gare du Midi)
No tags
Next departures for Lyon to Brussels on November 22
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Perrache
Brussels North Train Station
Cheapest
Bus
Perrache
Brussels South (Gare du Midi)
Fastest
Bus
Lyon - Perrache Bus Station
Brussels-South (Gare du Midi)
No tags
Bus
Aéroport LYS
Brussels North Train Station
No tags
Bus
Lyon - Perrache Bus Station
Brussels-South (Gare du Midi)
No tags
Next departures for Lyon to Brussels on November 23
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Perrache
Midi
Cheapest
Bus
Perrache
Brussels South (Gare du Midi)
Fastest
Bus
Lyon - Perrache Bus Station
Brussels-South (Gare du Midi)
No tags
Bus
Aéroport LYS
Brussels North Train Station
No tags
Bus
Aéroport LYS
Brussels North Train Station
No tags
Next departures for Lyon to Brussels on November 24
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Lyon - Perrache Bus Station
Brussels-South (Gare du Midi)
CheapestFastest
Bus
Lyon - Perrache Bus Station
Brussels-South (Gare du Midi)
No tags
Next departures for Lyon to Brussels on November 25
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Perrache
Brussels North Train Station
Cheapest
Bus
Perrache
Brussels South (Gare du Midi)
Fastest
Bus
Lyon - Perrache Bus Station
Brussels-South (Gare du Midi)
No tags
Bus
Aéroport LYS
Brussels North Train Station
No tags
Bus
Lyon - Perrache Bus Station
Brussels-South (Gare du Midi)
No tags
Next departures for Lyon to Brussels on November 27
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Lyon - Perrache Bus Station
Brussels-South (Gare du Midi)
CheapestFastest
Bus
Lyon - Perrache Bus Station
Brussels-South (Gare du Midi)
No tags
Bus
Lyon - Perrache Bus Station
Brussels-South (Gare du Midi)
No tags
Last refresh of the prices: Today at 12:42 AM CET.
Compare 3 ways to go from Lyon to Brussels
We recommend taking the train
Among the sustainable travel choices, the train stands out as a good way to reach Brussels. The journey takes about 4 hours 13 minutes, and with fares starting at just $100, it presents an excellent value for a comfortable ride.
Based on 11380 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the staff but often complained with the WiFi. FlixBus ticket prices on this trip start at $46
Based on 11143 reviews, the company was rated 3.7 stars on Busbud. Travellers were especially satisfied with the ticket access and the staff but often complained with the WiFi. BlaBlaCar Bus ticket prices on this trip start at $37
Frequently asked questions about travelling from Lyon to Brussels by bus
How far is Lyon from Brussels?
The distance covered from Lyon to Brussels is 569 km (353 miles).
What are the departure and arrival locations for buses traveling from Lyon to Brussels?
Buses traveling this route start their trip at Perrache, in Lyon, and end it at Brussels South (Gare du Midi), in Brussels.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
11-18
$124
11-19
$53
Today
$51
11-21
$73
11-22
$50
11-23
$61
11-24
$58
11-25
$43
The cheapest trip from Lyon to Brussels was searched and found on Nov 25, 2025 with a price of $43
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Lyon to Brussels, as early as possible.
You can expect to pay from $43 to $191 for a bus ticket from Lyon to Brussels based on the last 2 days. You can expect to find the cheapest price for the trip at $43 which is on 2025-11-25.
What's the cheapest way to go from Lyon to Brussels?
The bus is the cheapest travel choice for this destination
The cheapest trip from Lyon to Brussels was searched and found on Nov 25, 2025 with a price of $43
The bus is the cheapest travel choice for this destination
