Next departures for Lyon to Brussels on November 19
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Perrache
Brussels North Train Station
Cheapest
Bus
Perrache
Brussels South (Gare du Midi)
Fastest
Bus
Aéroport LYS
Brussels North Train Station
No tags
Bus
Aéroport LYS
Brussels North Train Station
No tags
Bus
Aéroport LYS
Brussels South (Gare du Midi)
No tags
Next departures for Lyon to Brussels on November 20
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Lyon - Perrache Bus Station
Brussels-South (Gare du Midi)
Cheapest
Bus
Perrache
Brussels South (Gare du Midi)
Fastest
Bus
Lyon - Perrache Bus Station
Brussels-South (Gare du Midi)
No tags
Bus
Aéroport LYS
Brussels North Train Station
No tags
Bus
Aéroport LYS
Brussels North Train Station
No tags
Next departures for Lyon to Brussels on November 21
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Perrache
Brussels South (Gare du Midi)
Cheapest
Bus
Perrache
Brussels South (Gare du Midi)
Fastest
Bus
Lyon - Perrache Bus Station
Brussels-South (Gare du Midi)
No tags
Bus
Aéroport LYS
Brussels North Train Station
No tags
Bus
Lyon - Perrache Bus Station
Brussels-South (Gare du Midi)
No tags
Next departures for Lyon to Brussels on November 22
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Perrache
Brussels North Train Station
Cheapest
Bus
Perrache
Brussels South (Gare du Midi)
Fastest
Bus
Lyon - Perrache Bus Station
Brussels-South (Gare du Midi)
No tags
Bus
Aéroport LYS
Brussels North Train Station
No tags
Bus
Lyon - Perrache Bus Station
Brussels-South (Gare du Midi)
No tags
Next departures for Lyon to Brussels on November 23
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Lyon - Perrache Bus Station
Brussels-South (Gare du Midi)
Cheapest
Bus
Perrache
Brussels South (Gare du Midi)
Fastest
Bus
Lyon - Perrache Bus Station
Brussels-South (Gare du Midi)
No tags
Bus
Aéroport LYS
Brussels North Train Station
No tags
Bus
Aéroport LYS
Brussels North Train Station
No tags
Next departures for Lyon to Brussels on November 24
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Lyon - Perrache Bus Station
Brussels-South (Gare du Midi)
CheapestFastest
Bus
Lyon - Perrache Bus Station
Brussels-South (Gare du Midi)
No tags
Next departures for Lyon to Brussels on November 25
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Perrache
Brussels North Train Station
Cheapest
Bus
Perrache
Brussels South (Gare du Midi)
Fastest
Bus
Lyon - Perrache Bus Station
Brussels-South (Gare du Midi)
No tags
Bus
Aéroport LYS
Brussels North Train Station
No tags
Bus
Lyon - Perrache Bus Station
Brussels-South (Gare du Midi)
No tags
Last refresh of the prices: Yesterday at 12:46 AM CET.
Compare 3 ways to go from Lyon to Brussels
We recommend taking the train
Among the sustainable travel choices, the train stands out as the good way to reach Brussels. The journey takes about 4 hours 13 minutes and with fares starting at just $69, it presents an excellent value for a comfortable ride.
Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.
Based on 11138 reviews, the company was rated 3.7 stars on Busbud. Travelers were especially satisfied with the ticket access and the staff but often complained with the wifi. BlaBlaCar Bus ticket prices on this trip start at $26
Frequently asked questions about traveling from Lyon to Brussels by bus
How far is Lyon from Brussels?
About 353 miles (569 km) separate Lyon and Brussels.
What are the departure and arrival stations when taking the bus from Lyon to Brussels?
Most of the buses traveling from Lyon to Brussels leave from Perrache and arrive at Brussels South (Gare du Midi). These are the main pick-up and drop-off locations on this route, there are other pick-up and drop-off locations that could make it easier for you to reach your destination.
What are the best sights and things to do in Brussels?
Once in Brussels, you can start exploring the city and discover its surroundings. The top sights and things to do are Bruxelles Les Bains - A beach in Brussels! The Iris events, Bright Brussels Festival, The Ommegang, Brussels' oldest historical pageant and Pride Festival in Brussels.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
11/17
$39
11/18
$87
Today
$37
11/20
$35
11/21
$51
11/22
$35
11/23
$41
11/24
$38
The cheapest trip from Lyon to Brussels was searched and found on Nov 20, 2025 with a price of $35
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Lyon to Brussels, as early as possible.
You can expect to pay from $35 to $133 for a bus ticket from Lyon to Brussels based on the last 2 days. You can expect to find the cheapest price for the trip at $35 which is on 2025-11-20.
Usually FlixBus will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
What's the cheapest way to go from Lyon to Brussels?
The bus is the cheapest travel choice for this destination
The cheapest trip from Lyon to Brussels was searched and found on Nov 20, 2025 with a price of $35
The bus is the cheapest travel choice for this destination
