Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Port St. Lucie (Park & Ride) | Tampa Bus Station | CheapestFastest | ||||
 | Bus | Port St. Lucie (Park & Ride) | Tampa Bus Station | No tags |
Last refresh of the prices: Last Wednesday at 4:36 PM EST.
Get from Port Saint Lucie to Tampa
The journey takes about 8 hours, and with fares starting at just $61, it presents an excellent value for a comfortable ride.
Where are the popular stops in Port Saint Lucie and Tampa?
Stops in Port Saint Lucie
- A
Port St Lucie Mobil Gas Bus Stop
1820 Sw Fountainview Blvd, Port Saint Lucie, FL 34986 - B
Port Saint Lucie - Wendys
1790 SW St Lucie W Blvd, Port St Lucie, FL 34986 - C
Port Saint LucieService Plaza
Florida's Turnpike, Milepost 144, Port St Lucie, FL 34984, USA - D
Port Saint Lucie Bus Stop
2198 SW Gatlin Blvd. Port St. Lucie, FL 34953
Stops in Tampa
- A
Tampa 13th Avenue Bus Stop (McDonald's)
2101 E 13th Ave (McDonald's), Tampa, FL 33605 - B
Tampa USF, FL
3801 USF Holly Drive, Tampa., FL 33620, USA - C
Greyhound Station
610 E Polk St, Tampa, FL 33602, USA - D
E Sligh Ave
11555 E Sligh Ave, Seffner, FL 33584, USA - E
N Marion St & E Laurel St
551 E Laurel St, Tampa, FL 33602, USA - F
Port of Tampa
200-298 FL-60, Tampa, FL 33602, USA
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Frequently asked questions about travelling from Port Saint Lucie to Tampa by bus
What is the travel distance from Port Saint Lucie to Tampa?
Port Saint Lucie and Tampa are 221 km (137 miles) apart.
What are the departure and arrival locations for buses traveling from Port Saint Lucie to Tampa?
Buses departing from Port St Lucie Mobil Gas Bus Stop in Port Saint Lucie will take you to Tampa 13th Avenue Bus Stop (McDonald's) in Tampa.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Port Saint Lucie to Tampa was searched and found on Nov 27, 2025 with a price of $73To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Port Saint Lucie to Tampa, as early as possible.
You can expect to pay from $73 to $141 for a bus ticket from Port Saint Lucie to Tampa based on the last 2 days. You can expect to find the cheapest price for the trip at $73 which is on 2025-11-27.
Usually Greyhound, FlixBus will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
Top travelled bus routes
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Popular bus departures from Port Saint Lucie
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