Find coaches from Panama City, US to Port Saint Lucie

Previously seen journeys

Next departures from Panama City to Port Saint Lucie on 1 November
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Greyhound + FlixBus
    		Panama City Beach Station
    		Port St Lucie (Park & Ride)No tags
    Greyhound + FlixBus
      		Panama City Beach Station
      		Port St. Lucie (Park & Ride)No tags
      Greyhound + FlixBus
        		Panama City Beach Station
        		Port St. Lucie (Park & Ride)No tags
        Greyhound + FlixBus
          		Panama City Beach Station
          		Port St. Lucie (Park & Ride)No tags
          FlixBus + Greyhound
            		Panama City Beach Station
            		Port St. Lucie (Park & Ride)No tags

            Accepted payments

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            Get from Panama City to Port Saint Lucie

            This route is served by bus only

            The journey takes about 17 hours 10 minutes, and with fares starting at just US$82, it presents an excellent value for a comfortable ride.

            2bus per day
            17h 10mAverage duration
            382 milesDistance
            15kgCO₂ emissions

            Bus Panama City, US to Port Saint Lucie: Trip Overview

            Average ticket priceUS$120
            Average bus trip duration17h 10m
            Number of daily buses2
            Earliest bus departure06:25
            Distance382 miles
            Latest bus departure12:50

            Panama City to Port Saint Lucie Bus

            Busbud helps you find a bus from Panama City to Port Saint Lucie. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

            Bus service from Panama City to Port Saint Lucie will be provided by the most trusted bus companies.

            Discover how much the bus trip from Panama City to Port Saint Lucie will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

            Frequently asked questions on the trip Panama City, US - Port Saint Lucie

            1. What's the distance between Panama City and Port Saint Lucie by coach?

              The journey from Panama City to Port Saint Lucie by coach covers an approximate distance of 378 miles (610 km).

            2. How can I travel from Panama City to Port Saint Lucie avoiding air travel?

              You can choose the coach to travel this route. Choosing the coach guarantees a comfortable and sustainable travel experience, allowing you to admire the views on your way to your destination. You also have the option of utilising carpooling services.

            Find cheapest prices for buses

            Price is for a one-way ticket for one passenger and based on past searches.

            Best price found
            29/10
            US$133
            30/10
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            busbud logoThe cheapest trip from Panama City, US to Port Saint Lucie was searched and found on 29 Oct 2025 with a price of US$133

            To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Panama City, US to Port Saint Lucie as early as possible.

            About Bus Travel

            Bus Travel Tips

            Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Panama City and Port Saint Lucie!

            Much more than a mere vehicle taking you from Panama City to Port Saint Lucie, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

            Buses have the smallest carbon footprint of all motorized transport modes. A bus going from Panama City to Port Saint Lucie will emit half the CO2 emitted by a train, and radically less than a car or an airplane.

            Tune out to the fine sounds of your best music playlist on your bus trip from Panama City to Port Saint Lucie while indulging in miles on end of beautiful scenic views.

            Did you know?

            Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!

            The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

            Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travellers have used their electronic device on board during 2014.

            Will you be returning to Panama City, US by bus?

            Bus from Port Saint Lucie to Panama City, US

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