Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Av. Balmaceda | Terminal de Buses La Serena | Cheapest | ||||
 | Bus | Terminal de buses Calama | Terminal de Buses La Serena | Fastest | ||||
| Bus | Calama | Terminal de Buses La Serena | No tags | ||||
| Bus | Av. Balmaceda | Terminal de Buses La Serena | No tags | ||||
 | Bus | Calama (Terminale de buses Granaderos) | La Serena (Bus terminal La Serena) | No tags | ||||
| Bus | Terminal de buses Calama | Terminal de Buses La Serena | No tags | ||||
| Bus | Av. Balmaceda | Terminal de Buses La Serena | No tags | ||||
| Bus | Calama (Terminale de buses Granaderos) | La Serena (Bus terminal La Serena) | No tags |
Last refresh of the prices: Today at 2:41 PM -04.
Get from Calama to La Serena
This route is served by bus only
The journey takes about 14 hours 5 minutes and with fares starting at just $29, it presents an excellent value for a comfortable ride.
18bus per day
14h 5mAverage Duration
534 milesDistance
22kgCO₂ emissions
Compare bus companies
4 out of 5 stars4/575 reviews
3.5 out of 5 stars3.5/5123 reviews
4 out of 5 stars4/554 reviews
3.5 out of 5 stars3.5/513 reviews
4.5 out of 5 stars4.5/53 reviews
CL bus companies: FlixBus, BlaBlaCar Bus, ALSA, Greyhound, Intercape, Trenitalia, Sindbad
Where are the popular stops in Calama and La Serena?
Stops in Calama
Stops in La Serena
Frequently asked questions about traveling from Calama to La Serena, CL by bus
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
11/08
$37
11/09
$33
Today
$38
11/11
$32
11/12
$32
11/13
$32
11/14
$32
11/15
$33
The cheapest trip from Calama to La Serena, CL was searched and found on Nov 14, 2025 with a price of $32To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Calama to La Serena, CL, as early as possible.
You can expect to pay from $32 to $48 for a bus ticket from Calama to La Serena, CL based on the last 2 days. You can expect to find the cheapest price for the trip at $32 which is on 2025-11-14.
Top traveled bus routes
People from around the world trust Busbud
Popular Buses Connecting Calama
Buses Leaving from Calama
- Bus from Calama to Iquique
- Bus Calama - La Serena
- Calama - Antofagasta
- Bus from Calama to Sierra Gorda
- Bus Calama - Copiapo
- Calama - Puerto Montt
- Bus from Calama to Arica Province
- Bus Calama - Vallenar
- Calama - Ovalle
- Bus from Calama to Pozo Almonte
- Bus Calama - Coquimbo
- Calama - Baquedano
- Bus from Calama to La Calera
- Bus Calama - Pullalli
- Calama - Taltal
Buses Going to Calama
- Bus from Copiapo to Calama
- Bus Iquique - Calama
- Sierra Gorda - Calama
- Bus from Uyuni to Calama
- Bus Coquimbo - Calama
- Salta - Calama
- Bus from Antofagasta to Calama
- Bus Arica Province - Calama
- La Serena - Calama
- Bus from Baquedano to Calama
- Bus Vallenar - Calama
- Taltal - Calama
- Bus from Ovalle to Calama
- Bus Alto Hospicio - Calama
- Pozo Almonte - Calama
Popular Buses Connecting La Serena
Buses Leaving from La Serena
- Bus from La Serena to Coquimbo
- Bus La Serena - Temuco
- La Serena - Ovalle
- Bus from La Serena to Antofagasta
- Bus La Serena - Vallenar
- La Serena - Vicuña
- Bus from La Serena to Calama
- Bus La Serena - Valparaiso
- La Serena - Copiapo
- Bus from La Serena to Caldera
- Bus La Serena - Los Vilos
- La Serena - La Calera
- Bus from La Serena to Quintero
- Bus La Serena - Tongoy
- La Serena - Llaillay
Buses Going to La Serena
- Bus from Ovalle to La Serena
- Bus Copiapo - La Serena
- Calama - La Serena
- Bus from Temuco to La Serena
- Bus Valparaiso - La Serena
- Vallenar - La Serena
- Bus from Antofagasta to La Serena
- Bus Vina del Mar - La Serena
- Vicuña - La Serena
- Bus from Caldera to La Serena
- Bus Coquimbo - La Serena
- Iquique - La Serena
- Bus from Arica Province to La Serena
- Bus Pucon - La Serena
- Taltal - La Serena
Popular routes in this country
- Bus from Santiago to Valparaiso
- Bus Santiago - Pucon
- Valparaiso - Santiago
- Bus from Puerto Natales to Estancia Pudeto
- Bus Santiago - Pichilemu
- Puerto Montt - Santiago
- Bus from Pucon to Puerto Montt
- Bus Puerto Montt - Pucon
- Calama - Santiago
- Bus from Osorno Province to Pucon
- Bus Santiago - Vina del Mar
- Santiago - La Serena
- Bus from Concepción to Santiago
- Bus Puerto Varas - Pucon
- La Serena - Santiago