Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.
Frequently asked questions about traveling from Charlotte, NC to Panama City, US by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Charlotte to Panama City?
The cheapest bus tickets from Charlotte to Panama City start from $113. The average price for this route is around $150. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Charlotte to Panama City?
The average bus trip duration from Charlotte to Panama City is 19h 15m, covering a distance of 449 miles (724 km). The quickest bus can get you there in 16h 30m and is operated by Greyhound.
Which bus companies service the Charlotte to Panama City route?
Several major bus companies operate on this route with 5 buses available per day, including services from Greyhound, FlixBus.
What is the earliest and latest departure time for the bus from Charlotte to Panama City?
The earliest bus departs from Charlotte to Panama City at 12:55am. And the latest bus departs at 10:30pm.
What are the CO₂ emissions for the bus trip from Charlotte to Panama City?
A bus trip from Charlotte to Panama City generates an estimated 18 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
What is the best bus company from Charlotte to Panama City?
According to Busbud customers, the highest-rated bus company on this route is Greyhound, with an average rating of 3.5 out of 5 stars based on 87500 reviews.
Which bus company has the best Wi-Fi from Charlotte to Panama City?
Based on reviews on Busbud, the bus company FlixBus has the best Wi-Fi rating with a score of 2.7.
Which bus company has the most timely service from Charlotte to Panama City?
According to Busbud traveller reviews, the most timely bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Charlotte to Panama City?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
01/16
$123
01/17
$127
Today
$124
01/19
$130
01/20
$105
01/21
$109
01/22
$115
01/23
No data
The cheapest trip from Charlotte, NC to Panama City, US was searched and found on Jan 20, 2026 with a price of $105
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Charlotte, NC to Panama City, US, as early as possible.
You can expect to pay from $105 to $133 for a bus ticket from Charlotte, NC to Panama City, US based on the last 2 days. You can expect to find the cheapest price for the trip at $105 which is on 2026-01-20.
The cheapest trip from Charlotte, NC to Panama City, US was searched and found on Jan 20, 2026 with a price of $105
