Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound Lines, Inc. + FlixBus | Bus | Des Moines | Gateway Station | CheapestFastest | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Des Moines | Gateway Station | No tags |
Last refresh of the prices: Today at 10:08 AM CST.
Get from Des Moines to St. Louis
The journey takes about 17 hours 40 minutes and with fares starting at just $83, it presents an excellent value for a comfortable ride.
Where are the popular stops in Des Moines and St. Louis?
Stops in Des Moines
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Frequently asked questions about traveling from Des Moines to St. Louis by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Des Moines to St. Louis?
The cheapest bus tickets from Des Moines to St. Louis start from $83. The average price for this route is around $160. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Des Moines to St. Louis?
The average bus trip duration from Des Moines to St. Louis is 17h 40m, covering a distance of 274 miles (441 km). The quickest bus can get you there in 8h and is operated by Jefferson Lines.
Which bus companies service the Des Moines to St. Louis route?
Several major bus companies operate on this route with 1 buses available per day, including services from Greyhound, Jefferson Lines, Burlington Trailways.
What is the earliest and latest departure time for the bus from Des Moines to St. Louis?
The earliest bus departs from Des Moines to St. Louis at 5:30am. And the latest bus departs at 10:00am.
What are the CO₂ emissions for the bus trip from Des Moines to St. Louis?
A bus trip from Des Moines to St. Louis generates an estimated 11 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
What is the best bus company from Des Moines to St. Louis?
According to Busbud customers, the highest-rated bus company on this route is Burlington Trailways, with an average rating of 4.2 out of 5 stars based on 20 reviews.
Which bus company has the best Wi-Fi from Des Moines to St. Louis?
Based on reviews on Busbud, the bus company Burlington Trailways has the best Wi-Fi rating with a score of 5.0.
Which bus company has the most timely service from Des Moines to St. Louis?
According to Busbud traveller reviews, the most timely bus company on this route is Burlington Trailways, with a punctuality rating of 5.0 out of 5 stars.
Which bus company has the cleanest buses from Des Moines to St. Louis?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is Burlington Trailways, with a cleanliness rating of 5.0 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Des Moines to St. Louis was searched and found on Jan 15, 2026 with a price of $116To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Des Moines to St. Louis, as early as possible.
Top traveled bus routes
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Popular bus departures from Des Moines
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