Bus Tickets from Des Moines to St. Louis

TodayJul 31
TomorrowAug 1
SatAug 2
from $113
SunAug 3
MonAug 4
TueAug 5
WedAug 6
from $103
ThuAug 7
from $91

Cheap buses leaving Saturday

One passenger / one way

  • This trip is recommended because it is: Cheapest + Fastest
    Departure time: August 2 at
    Departure city: Des Moines
    Departure location: Des Moines (Subway)
    Arrival time: August 2 at
    Destination city: St. Louis
    Destination location: Gateway Station
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:

Accepted payments

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Bus Des Moines to St. Louis: Trip Overview

Average ticket price$104
Average bus trip duration17h 35m
Number of daily buses1
Earliest bus departure5:30am
Distance274 miles (441 km)
Latest bus departure8:15am

Des Moines to St. Louis Bus

Busbud helps you find a bus from Des Moines to St. Louis. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

We make it our job to connect you with the most dependable bus companies that cover bus service from Des Moines to St. Louis.

Whether it is cheap bus tickets or more luxurious buses going to St. Louis from Des Moines, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions for your trip Des Moines - St. Louis

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
07/29
No data
07/30
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Today
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08/01
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08/02
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08/03
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08/04
$106
08/05
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busbud logoThe cheapest trip from Des Moines to St. Louis was searched and found on Aug 4, 2025 with a price of $106

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Des Moines to St. Louis, as early as possible.

You can expect to pay from $106 to $146 for a bus ticket from Des Moines to St. Louis based on the last 2 days. You can expect to find the cheapest price for the trip at $106 which is on 2025-08-04.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Des Moines and St. Louis!

From miles long of beauteous natural landscapes to impressive man-crafted sights, you're bound to be in for a visual treat on your bus trip from Des Moines to St. Louis.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Des Moines to St. Louis.

Tune out to the fine sounds of your best music playlist on your bus trip from Des Moines to St. Louis while indulging in miles on end of beautiful scenic views.

Did you know?

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travelers have used their electronic device on board during 2014.

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

Will you be returning to Des Moines by bus?

Bus from Des Moines to St. Louis

Why choose Busbud?

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