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- This trip is recommended because it is: CheapestDeparture time: June 5 atDeparture city: DetroitDeparture location: Detroit Bus StationArrival time: June 6 atDestination city: KnoxvilleDestination location: Knoxville Bus StationOperated by: Greyhound Lines, Inc.
Vehicle: BusDuration: - This trip is recommended because it is: FastestDeparture time: June 5 atDeparture city: DetroitDeparture location: Detroit Bus StationArrival time: June 5 atDestination city: KnoxvilleDestination location: Knoxville Bus StationOperated by: Greyhound Lines, Inc.Vehicle: BusDuration:
- Departure time: June 5 atDeparture city: DetroitDeparture location: Detroit Bus StationArrival time: June 5 atDestination city: KnoxvilleDestination location: Knoxville Bus StationOperated by: Greyhound Lines, Inc.Vehicle: BusDuration:
- Departure time: June 5 atDeparture city: DetroitDeparture location: Detroit Bus StationArrival time: June 6 atDestination city: KnoxvilleDestination location: Knoxville Bus StationOperated by: Greyhound Lines, Inc.Vehicle: BusDuration:
- Departure time: June 5 atDeparture city: DetroitDeparture location: Detroit Bus StationArrival time: June 6 atDestination city: KnoxvilleDestination location: Knoxville Bus StationOperated by: Greyhound Lines, Inc.Vehicle: BusDuration:
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Bus Detroit to Knoxville: Trip Overview
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Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Greyhound Detroit Knoxville recent customer reviews
Very late arrival
Ronell W.
The drivers were awesome. Trip was very comfortable.
Juliana T.
Detroit to Knoxville Bus
Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from Detroit to Knoxville.
We make it our job to connect you with the most dependable bus companies that cover bus service from Detroit to Knoxville.
From cheap bus tickets to more luxurious buses traveling from Detroit to Knoxville, we offer a wide range of bus services to best suit your needs depending on how much your budget is.
Where are the popular stops in Detroit and Knoxville?
Frequently asked questions for your trip Detroit (MI) - Knoxville (TN)
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Detroit to Knoxville was searched and found on Jun 5, 2025 with a price of $93To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Detroit to Knoxville, as early as possible.
About Bus Travel
Bus Travel Tips
If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from Detroit to Knoxville but it'll also be endearing to native speakers who will surely appreciate your effort.
From miles long of beauteous natural landscapes to impressive man-crafted sights, you're bound to be in for a visual treat on your bus trip from Detroit to Knoxville.
Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Detroit to Knoxville that are otherwise impossible to come by with a plane.
Tune out to the fine sounds of your best music playlist on your bus trip from Detroit to Knoxville while indulging in miles on end of beautiful scenic views.
Did you know?
9.2% of ground transportation in Europe is done by bus versus 7.4% by train.
The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.
One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.
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Busbud makes bus travel easy. We help travelers find a bus, plot routes, and book intercity bus tickets all over the world. With several language and currency options available, Busbud seeks to cater to international bus travelers no matter where they are in the world. Busbud prides itself on its worldwide partnerships. We make it possible for you to buy tickets with its large network of trustworthy bus partners like Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.
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Popular Buses Connecting Detroit
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Popular Buses Connecting Knoxville
Buses Leaving from Knoxville
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Buses Going to Knoxville
- Bus from Nashville to Knoxville
- Bus Memphis - Knoxville
- Charlotte - Knoxville
- Bus from Chicago to Knoxville
- Bus Tampa - Knoxville
- Detroit - Knoxville
- Bus from Atlanta to Knoxville
- Bus New York - Knoxville
- Greenville - Knoxville
- Bus from Dallas to Knoxville
- Bus Louisville - Knoxville
- Cookeville - Knoxville
- Bus from Lexington to Knoxville
- Bus Baltimore - Knoxville
- Cincinnati - Knoxville