Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Detroit Bus Station | Knoxville Bus Station | Cheapest | ||||
| Bus | Detroit Bus Station | Knoxville Bus Station | Fastest | ||||
| Bus | Detroit Bus Station | Knoxville Bus Station | No tags |
Last refresh of the prices: Yesterday at 12:24 PM EST.
Get from Detroit to Knoxville
The journey takes about 21 hours 25 minutes and with fares starting at just $68, it presents an excellent value for a comfortable ride.
Where are the popular stops in Detroit and Knoxville?
Stops in Knoxville
- AKnoxville Area Transit Bus Stop, 100 Kirkwood St, Knoxville, TN 37914, USA
Compare bus companies
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Greyhound Detroit Knoxville recent customer reviews
Very late arrival
Ronell W.
The drivers were awesome. Trip was very comfortable.
Juliana T.
Frequently asked questions about traveling from Detroit, MI to Knoxville, TN by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Detroit to Knoxville?
The cheapest bus tickets from Detroit to Knoxville start from $68. The average price for this route is around $122. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Detroit to Knoxville?
The average bus trip duration from Detroit to Knoxville is 21h 25m, covering a distance of 439 miles (708 km). The quickest bus can get you there in 12h 15m and is operated by Greyhound.
Which bus companies service the Detroit to Knoxville route?
Several major train operators operate on this route with 4 trains available per day.
What is the earliest and latest departure time for the bus from Detroit to Knoxville?
The earliest bus departs from Detroit to Knoxville at 6:40am. And the latest bus departs at 11:25pm.
What are the CO₂ emissions for the bus trip from Detroit to Knoxville?
A bus trip from Detroit to Knoxville generates an estimated 18 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Detroit, MI to Knoxville, TN was searched and found on Jan 8, 2026 with a price of $62To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Detroit, MI to Knoxville, TN, as early as possible.
You can expect to pay from $62 to $106 for a bus ticket from Detroit, MI to Knoxville, TN based on the last 2 days. You can expect to find the cheapest price for the trip at $64 which is on 2026-01-11.
