How far is Detroit from Knoxville?

The distance between the two cities is 443 miles (714 km).

What are the departure and arrival stations when taking the bus from Detroit to Knoxville?

Buses traveling from Detroit to Knoxville leave from Detroit Bus Station and arrive at 100 Kirkwood St.

Bus Detroit to Knoxville from $60 | Refundable Tickets

Previously seen trips

Next departures for Detroit to Knoxville on November 13
Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Bus	7:00am	Detroit Bus Station	11h 25m	6:25pm	Knoxville Bus Station	No tags
Bus	8:15pm	Detroit Bus Station	22h 20m	6:35pm	Knoxville Bus Station	No tags
Bus	6:40am	Detroit Bus Station	12h 15m	6:55pm	Knoxville Bus Station	No tags
Bus	7:00am	Detroit Bus Station	11h 25m	6:25pm	Knoxville Bus Station	No tags
Bus	9:00pm	Detroit Bus Station	21h 55m	6:55pm	Knoxville Bus Station	No tags

Get from Detroit to Knoxville

This route is served by bus only

The journey takes about 21 hours 45 minutes and with fares starting at just $47, it presents an excellent value for a comfortable ride.

4bus per day

21h 45mAverage Duration

439 milesDistance

18kgCO₂ emissions

Compare bus companies

Greyhound

3.5/587,370 reviews

Staff3.6

Timeliness2.9

Cleanliness3.3

Wifi2.4

Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.

Greyhound Detroit Knoxville recent customer reviews

Very late arrival

Ronell W.

August 22, 2020

The drivers were awesome. Trip was very comfortable.

Juliana T.

March 6, 2019

US bus companies: FlixBus, BlaBlaCar Bus, ALSA, Greyhound, Intercape, Trenitalia, Sindbad

Where are the popular stops in Detroit and Knoxville?

Stops in Detroit

A - Detroit Bus Station

Stops in Knoxville

A - 100 Kirkwood St

Frequently asked questions about traveling from Detroit, MI to Knoxville, TN by bus

How far is Detroit from Knoxville?
What are the departure and arrival stations when taking the bus from Detroit to Knoxville?

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

11/10

No data

11/11

$77

Today

$69

11/13

$64

11/14

No data

11/15

No data

11/16

$60

11/17

No data

The cheapest trip from Detroit, MI to Knoxville, TN was searched and found on Nov 16, 2025 with a price of $60

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Detroit, MI to Knoxville, TN, as early as possible.

You can expect to pay from $60 to $87 for a bus ticket from Detroit, MI to Knoxville, TN based on the last 2 days. You can expect to find the cheapest price for the trip at $60 which is on 2025-11-16.