Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Detroit Bus Station | Panama City Beach Station | CheapestFastest | ||||
| Bus | Detroit Bus Station | Panama City Beach Station | No tags |
Last refresh of the prices: Last Monday at 3:20 PM EST.
Get from Detroit to Panama City
The journey takes about 1 day, 3 hours 5 minutes and with fares starting at just $126, it presents an excellent value for a comfortable ride.
Where are the popular stops in Detroit and Panama City?
Compare bus companies
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Frequently asked questions about traveling from Detroit, MI to Panama City, US by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Detroit to Panama City?
The cheapest bus tickets from Detroit to Panama City start from $126. The average price for this route is around $187. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Detroit to Panama City?
The average bus trip duration from Detroit to Panama City is 1d 3h, covering a distance of 851 miles (1372 km). The quickest bus can get you there in 1d 3h and is operated by Greyhound.
Which bus companies service the Detroit to Panama City route?
Several major train operators operate on this route with 1 trains available per day.
What is the earliest and latest departure time for the bus from Detroit to Panama City?
The earliest bus departs from Detroit to Panama City at 6:40am. And the latest bus departs at 7:30pm.
What are the CO₂ emissions for the bus trip from Detroit to Panama City?
A bus trip from Detroit to Panama City generates an estimated 34 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Detroit, MI to Panama City, US was searched and found on Jan 17, 2026 with a price of $136To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Detroit, MI to Panama City, US, as early as possible.
You can expect to pay from $136 to $161 for a bus ticket from Detroit, MI to Panama City, US based on the last 2 days. You can expect to find the cheapest price for the trip at $136 which is on 2026-01-17.
