Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound Lines, Inc. + FlixBus | Bus | Detroit Bus Station | San Ysidro Bus terminal | Cheapest | ||||
FlixBus + Greyhound Lines, Inc. | Bus | Detroit Bus Station | San Ysidro Bus terminal | Fastest | ||||
FlixBus + Greyhound Lines, Inc. | Bus | Detroit Bus Station | San Ysidro Greyhound Bus Station | No tags | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Detroit Bus Station | San Ysidro Greyhound Bus Station | No tags |
Last refresh of the prices: Last Thursday at 10:10 PM EST.
Get from Detroit to San Ysidro
The journey takes about 2 days, 13 hours 25 minutes and with fares starting at just $224, it presents an excellent value for a comfortable ride.
Where are the popular stops in Detroit and San Ysidro?
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Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Frequently asked questions about traveling from Detroit, MI to San Ysidro, CA by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Detroit to San Ysidro?
The cheapest bus tickets from Detroit to San Ysidro start from $224. The average price for this route is around $250. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Detroit to San Ysidro?
The average bus trip duration from Detroit to San Ysidro is 2d 13h, covering a distance of 1963 miles (3166 km). The quickest bus can get you there in 2d 14h and is operated by Greyhound.
Which bus companies service the Detroit to San Ysidro route?
Several major train operators operate on this route with 3 trains available per day.
What is the earliest and latest departure time for the bus from Detroit to San Ysidro?
The earliest bus departs from Detroit to San Ysidro at 6:40am. And the latest bus departs at 11:25pm.
What are the CO₂ emissions for the bus trip from Detroit to San Ysidro?
A bus trip from Detroit to San Ysidro generates an estimated 79 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Detroit, MI to San Ysidro, CA was searched and found on Jan 15, 2026 with a price of $223To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Detroit, MI to San Ysidro, CA, as early as possible.
You can expect to pay from $223 to $223 for a bus ticket from Detroit, MI to San Ysidro, CA based on the last 2 days. You can expect to find the cheapest price for the trip at $223 which is on 2026-01-22.
