Bus Tickets from Florence, SC, US to Boston, MA, US
Next bus departures
Next departures for Florence to Boston on November 22
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Departure location
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Recommended
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Greyhound Lines, Inc. + FlixBus
Bus
Bus station
Boston (South Station)
Cheapest
FlixBus + Greyhound Lines, Inc.
Bus
Florence, SC
Boston (South Station)
Fastest
Greyhound Lines, Inc. + FlixBus
Bus
Bus station
151 Steel Pl, Cambridge
No tags
Bus
Florence, SC
Brookline
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FlixBus + Greyhound Lines, Inc.
Bus
Florence, SC
Boston (South Station)
No tags
Last refresh of the prices: Yesterday at 6:52 PM EST.
Compare 2 ways to go from Florence to Boston
We recommend taking the train
Among the sustainable travel choices, the train stands out as the good way to reach Boston. The journey takes about 19 hours 32 minutes and with fares starting at just $138, it presents an excellent value for a comfortable ride.
Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Frequently asked questions about traveling from Florence, SC, US to Boston, MA, US by bus
What is the distance between Florence and Boston?
Florence and Boston are 729 miles (1176 km) apart.
What are the departure and arrival stations when taking the bus from Florence to Boston?
If you're headed to Boston from Florence, chances are that your bus will depart from Florence Bus Station and arrive at Back Bay Station. These are the main departure and arrival locations on this route, but you could find others that could be a better fit for your travel plans.
What are the best sights and things to do in Boston?
Once in Boston, you can start exploring the city and discover its surroundings. The top sights and things to do are Boston Open Studios, Freedom Trail, Public Garden, Duck Tour and North End.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
11/18
$100
11/19
No data
Today
No data
11/21
No data
11/22
$158
11/23
$185
11/24
$147
11/25
$130
The cheapest trip from Florence, SC, US to Boston, MA, US was searched and found on Nov 18, 2025 with a price of $100
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Florence, SC, US to Boston, MA, US, as early as possible.
You can expect to pay from $100 to $185 for a bus ticket from Florence, SC, US to Boston, MA, US based on the last 2 days. You can expect to find the cheapest price for the trip at $130 which is on 2025-11-25.
What's the cheapest way to go from Florence, SC, US to Boston, MA, US?
The bus is the cheapest travel choice for this destination
The cheapest trip from Florence, SC, US to Boston, MA, US was searched and found on Nov 18, 2025 with a price of $100
The bus is the cheapest travel choice for this destination
