How much is the bus ticket from Greenville to Syracuse?

The cheapest bus tickets from Greenville to Syracuse start from $143. The average price for this route is around $187. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.

How long is the bus ride from Greenville to Syracuse?

The average bus trip duration from Greenville to Syracuse is 21h 40m, covering a distance of 657 miles (1059 km). The quickest bus can get you there in 20h 35m and is operated by FlixBus .

Which bus companies service the Greenville to Syracuse route?

Several major bus companies operate on this route with 3 buses available per day, including services from Greyhound , FlixBus .

What is the earliest and latest departure time for the bus from Greenville to Syracuse?

The earliest bus departs from Greenville to Syracuse at 7:25am. And the latest bus departs at 10:00pm.

What are the CO₂ emissions for the bus trip from Greenville to Syracuse?

A bus trip from Greenville to Syracuse generates an estimated 26 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.

What is the best bus company from Greenville to Syracuse?

According to Busbud customers, the highest-rated bus company on this route is Greyhound , with an average rating of 3.5 out of 5 stars based on 87387 reviews.

Which bus company has the best Wi-Fi from Greenville to Syracuse?

Based on reviews on Busbud, the bus company FlixBus has the best Wi-Fi rating with a score of 2.7.

Which bus company has the most timely service from Greenville to Syracuse?

According to Busbud traveller reviews, the most timely bus company on this route is FlixBus , with a punctuality rating of 3.9 out of 5 stars.

Which bus company has the cleanest buses from Greenville to Syracuse?

According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus , with a cleanliness rating of 4.1 out of 5 stars.

Bus Greenville to Syracuse from $196 | Refundable Tickets

Next bus departures

Next departures for Greenville to Syracuse on December 2
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
FlixBus + Greyhound Lines, Inc.	Bus	10:00pm	1116 Woodruff Rd	21h 30m	7:30pm	Syracuse (Regional Transportation Center)	CheapestFastest
Greyhound Lines, Inc. + FlixBus	Bus	7:25am	1116 Woodruff Rd	21h 40m	5:05am	Syracuse (Regional Transportation Center)	No tags
	Bus	10:50am	1116 Woodruff Rd	1d 2h	1:45pm	Syracuse (Regional Transportation Center)	No tags

Last refresh of the prices: Today at 9:37 AM EST.

Get from Greenville to Syracuse

This route is served by bus only

The journey takes about 21 hours 40 minutes and with fares starting at just $143, it presents an excellent value for a comfortable ride.

3bus per day

21h 40mAverage Duration

657 milesDistance

26kgCO₂ emissions

Where are the popular stops in Greenville and Syracuse?

Stops in Greenville

A
Guadalajara Supermarket Bus Stop
2803 White Horse Rd, Greenville, SC 29611
B
Greenville Bus Station
9 Hendrix DR, Greenville, SC 29607

Stops in Syracuse

A
Regional Transportation Center
1 Walsh Circle Ste 30, Syracuse, NY 13208
Visit page
B
Syracuse Airport
Visit page
C
Syracuse University
Bus stops at Schine Student Center across the street from the Sheraton Parking Garage., Schine Student Center, 303 University Pl, Syracuse, NY 13210
Visit page
D
Syracuse University - Lyman Hall
College Place, Syracuse, NY 13210, USA
E
New York State Fairgrounds
581 State Fair Blvd, Syracuse, NY 13209, USA
F
Syracuse, NY
349-399 US-11, Syracuse, NY 13202, USA

Compare bus companies

Greyhound

3.5/587,410 reviews

Staff3.6

Timeliness2.9

Cleanliness3.3

Wifi2.4

Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.

Greyhound Greenville Syracuse recent customer reviews

Very BAD Late Buses Had unexpected unplanned Delays and had to reschedule twice in route Because missed connections

Laureen D.

April 20, 2023

FlixBus

3.5/511,488 reviews

Staff4.2

Timeliness3.9

Cleanliness4.1

Wifi2.7

Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.

US bus companies: FlixBus, BlaBlaCar Bus, ALSA, Greyhound, Intercape, Trenitalia, Sindbad

Frequently asked questions about traveling from Greenville, SC to Syracuse, US by bus

Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.

How much is the bus ticket from Greenville to Syracuse?
The cheapest bus tickets from Greenville to Syracuse start from $143. The average price for this route is around $187. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Greenville to Syracuse?
The average bus trip duration from Greenville to Syracuse is 21h 40m, covering a distance of 657 miles (1059 km). The quickest bus can get you there in 20h 35m and is operated by FlixBus.
Which bus companies service the Greenville to Syracuse route?
Several major bus companies operate on this route with 3 buses available per day, including services from Greyhound, FlixBus.
What is the earliest and latest departure time for the bus from Greenville to Syracuse?
The earliest bus departs from Greenville to Syracuse at 7:25am. And the latest bus departs at 10:00pm.
What are the CO₂ emissions for the bus trip from Greenville to Syracuse?
A bus trip from Greenville to Syracuse generates an estimated 26 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
What is the best bus company from Greenville to Syracuse?
According to Busbud customers, the highest-rated bus company on this route is Greyhound, with an average rating of 3.5 out of 5 stars based on 87387 reviews.
Which bus company has the best Wi-Fi from Greenville to Syracuse?
Based on reviews on Busbud, the bus company FlixBus has the best Wi-Fi rating with a score of 2.7.
Which bus company has the most timely service from Greenville to Syracuse?
According to Busbud traveller reviews, the most timely bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Greenville to Syracuse?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

11/29

No data

11/30

No data

Today

No data

12/02

$196

12/03

No data

12/04

No data

12/05

No data

12/06

No data

The cheapest trip from Greenville, SC to Syracuse, US was searched and found on Dec 2, 2025 with a price of $196

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Greenville, SC to Syracuse, US, as early as possible.

You can expect to pay from $196 to $196 for a bus ticket from Greenville, SC to Syracuse, US based on the last 2 days. You can expect to find the cheapest price for the trip at $196 which is on 2025-12-02.