How can I travel from Greenville to Syracuse without flying?

Taking the bus is the best way to travel to Syracuse without flying. The bus trip is an affordable, safe and convenient way to travel between the two cities. Taking a ride with other travelers through carpool services is an additional option to consider.

How long does it take to get to Syracuse from Greenville by bus?

On average, the trip from Greenville to Syracuse takes around 22h 25m, although the fastest bus will take 20h 35m, on average. This is the time it takes to travel the 658 miles (1060 km) that separate the two cities.

What is the travel distance from Greenville to Syracuse?

The distance separating Greenville and Syracuse is 658 miles (1060 km).

What are the departure and arrival stations when taking the bus from Greenville to Syracuse?

The majority of buses traveling from Greenville to Syracuse start their journey at Guadalajara Supermarket Bus Stop and wind up at Syracuse Airport. These are the most popular departure and arrival locations on this route, but you could find others that could be a better fit for your travel plans.

What is the most cost-effective way to get from Greenville to Syracuse?

Go for the bus if you want the most economical way to travel this route. With prices starting at $97, you won't find a cheaper way to get there.

How much are the bus tickets from Greenville to Syracuse?

You can expect to pay around $162 for a bus ticket. In the last 30 days, the prices ranged from $97 to $333, so it's good to do your research before booking.

What are the best sights and things to do in Syracuse?

Once in Syracuse, you can start exploring the city and discover its surroundings. The top sights and things to do are Central New York Playhouse, Onondaga Lake Park, WonderWorks, Regal Destiny USA Stadium 19 IMAX & RPX and Rosamond Gifford Zoo.

Is there an overnight bus from Greenville to Syracuse?

Certainly! You can indeed opt for an overnight bus from Greenville to Syracuse. Make sure to pack a blanket and a snack to make your trip more comfortable.

Greenville (SC) to Syracuse, US Bus Tickets

TodayJun 8

TomorrowJun 9

TueJun 10

from $177

WedJun 11

from $164

ThuJun 12

FriJun 13

from $274

SatJun 14

SunJun 15

Cheap buses leaving Tuesday

One passenger / one way

This trip is recommended because it is: Cheapest
Departure time: June 10 at 7:40am
Departure city: Greenville
Departure location: 1116 Woodruff Rd
Arrival time: June 11 at 5:05am
Destination city: Syracuse
Destination location: Syracuse (Regional Transportation Center)
Operated by: Greyhound Lines, Inc. + FlixBus
Greyhound Lines, Inc. + FlixBus
Vehicle: BusDuration: 21h 25m
This trip is recommended because it is: Fastest
Departure time: June 10 at 8:30pm
Departure city: Greenville
Departure location: 1116 Woodruff Rd
Arrival time: June 11 at 5:25pm
Destination city: Syracuse
Destination location: Syracuse (Regional Transportation Center)
Operated by: FlixBus + Greyhound Lines, Inc.
FlixBus + Greyhound Lines, Inc.
Vehicle: BusDuration: 20h 55m
Departure time: June 10 at 10:50am
Departure city: Greenville
Departure location: 1116 Woodruff Rd
Arrival time: June 11 at 11:20am
Destination city: Syracuse
Destination location: Syracuse (Regional Transportation Center)
Operated by: Greyhound Lines, Inc.
Vehicle: BusDuration: 1d
Departure time: June 10 at 4:20pm
Departure city: Greenville
Departure location: 1116 Woodruff Rd
Arrival time: June 11 at 3:15pm
Destination city: Syracuse
Destination location: Syracuse (Regional Transportation Center)
Operated by: FlixBus + Greyhound Lines, Inc.
FlixBus + Greyhound Lines, Inc.
Vehicle: BusDuration: 22h 55m
Departure time: June 10 at 8:30pm
Departure city: Greenville
Departure location: 1116 Woodruff Rd
Arrival time: June 11 at 5:25pm
Destination city: Syracuse
Destination location: Syracuse (Regional Transportation Center)
Operated by: FlixBus + Greyhound Lines, Inc.
FlixBus + Greyhound Lines, Inc.
Vehicle: BusDuration: 20h 55m

Accepted payments

Bus Greenville to Syracuse: Trip Overview

Average ticket price$162

Average bus trip duration22h 25m

Number of daily buses5

Earliest bus departure7:40am

Distance657 miles (1059 km)

Latest bus departure10:00pm

Compare bus companies

Greyhound

3.5/587,024 reviews

Staff3.6

Timeliness2.8

Cleanliness3.3

Wifi2.3

Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.

Greyhound Greenville Syracuse recent customer reviews

Very BAD Late Buses Had unexpected unplanned Delays and had to reschedule twice in route Because missed connections

Laureen D.

April 20, 2023

FlixBus

3.5/58,946 reviews

Staff4.1

Timeliness4

Cleanliness4.1

Wifi2.7

Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.

US bus companies: FlixBus, Greyhound, Tornado Bus, Los Limousines, Valley Transit, Tufesa, Wanda Coach

Greenville to Syracuse Bus

With Busbud, comparing and booking tickets for a bus from Greenville to Syracuse is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

We make it our job to connect you with the most dependable bus companies that cover bus service from Greenville to Syracuse.

Discover how much the bus trip from Greenville to Syracuse will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Where are the popular stops in Greenville and Syracuse?

Stops in Greenville

A - Guadalajara Supermarket Bus Stop

B - Greenville Bus Station

Stops in Syracuse

A - Syracuse Airport

B - Regional Transportation Center

C - Syracuse University

D - Syracuse University - Lyman Hall

E - New York State Fairgrounds

F - Syracuse, NY

Frequently asked questions for your trip Greenville (SC) - Syracuse, US

How can I travel from Greenville to Syracuse without flying?
How long does it take to get to Syracuse from Greenville by bus?
What is the travel distance from Greenville to Syracuse?
What are the departure and arrival stations when taking the bus from Greenville to Syracuse?
What is the most cost-effective way to get from Greenville to Syracuse?
How much are the bus tickets from Greenville to Syracuse?
What are the best sights and things to do in Syracuse?
Is there an overnight bus from Greenville to Syracuse?

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

06/06

No data

06/07

No data

Today

No data

06/09

No data

06/10

$199

06/11

$187

06/12

No data

06/13

No data

The cheapest trip from Greenville to Syracuse was searched and found on Jun 11, 2025 with a price of $187

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Greenville to Syracuse, as early as possible.

You can expect to pay from $187 to $199 for a bus ticket from Greenville to Syracuse based on the last 2 days. You can expect to find the cheapest price for the trip at $187 which is on 2025-06-11.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while traveling from Greenville to Syracuse.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

From miles long of beauteous natural landscapes to impressive man-crafted sights, you're bound to be in for a visual treat on your bus trip from Greenville to Syracuse.

Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from Greenville to Syracuse will emit less CO2 than a car or an airplane.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Greenville to Syracuse.

Did you know?

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

Will you be returning to Greenville by bus?

Bus from Greenville to Syracuse

Top traveled bus routes

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud.com makes it easy for you to find, compare and book city-to-city bus tickets, all over the world. We save you the extra trip to the bus station. With Busbud, wherever you go, you have a worldwide bus station within reach and available in your own language and currency. With Busbud, you can buy tickets with confidence. We ensure that you make the most out of your bus trip by partnering up with reliable bus companies from all around the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

Bus Tickets from Greenville (SC) to Syracuse, US

Cheap buses leaving Tuesday

One passenger / one way

One passenger / one way

One passenger / one way

Bus Greenville to Syracuse: Trip Overview

Compare bus companies

Greyhound Greenville Syracuse recent customer reviews

Greenville to Syracuse Bus

Where are the popular stops in Greenville and Syracuse?

Frequently asked questions for your trip Greenville (SC) - Syracuse, US

How can I travel from Greenville to Syracuse without flying?

How long does it take to get to Syracuse from Greenville by bus?

What is the travel distance from Greenville to Syracuse?

What are the departure and arrival stations when taking the bus from Greenville to Syracuse?

What is the most cost-effective way to get from Greenville to Syracuse?

How much are the bus tickets from Greenville to Syracuse?

What are the best sights and things to do in Syracuse?

Is there an overnight bus from Greenville to Syracuse?

Find cheapest prices for buses

About Bus Travel

Bus Travel Tips

Did you know?

Will you be returning to Greenville by bus?

Top traveled bus routes

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

People from around the world trust Busbud

Popular Buses Connecting Greenville

Buses Leaving from Greenville

Buses Going to Greenville

Popular Buses Connecting Syracuse

Buses Leaving from Syracuse

Buses Going to Syracuse

Popular routes in this country

Popular airport transfers