Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Bus Station | 1116 Woodruff Rd | CheapestFastest |
Last refresh of the prices: Last Friday at 12:09 PM EST.
Get from Myrtle Beach to Greenville
The journey takes about 17 hours 10 minutes and with fares starting at just $96, it presents an excellent value for a comfortable ride.
Where are the popular stops in Myrtle Beach and Greenville?
Stops in Greenville
- A
Guadalajara Supermarket Bus Stop
2803 White Horse Rd, Greenville, SC 29611 - B
Greenville Bus Station
9 Hendrix DR, Greenville, SC 29607
Compare bus companies
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Frequently asked questions about traveling from Myrtle Beach to Greenville, SC by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Myrtle Beach to Greenville?
The cheapest bus tickets from Myrtle Beach to Greenville start from $96. The average price for this route is around $147. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Myrtle Beach to Greenville?
The average bus trip duration from Myrtle Beach to Greenville is 17h 10m, covering a distance of 211 miles (339 km). The quickest bus can get you there in 17h 10m and is operated by Greyhound.
Which bus companies service the Myrtle Beach to Greenville route?
Several major bus companies operate on this route with 1 buses available per day.
What is the earliest and latest departure time for the bus from Myrtle Beach to Greenville?
The earliest bus departs from Myrtle Beach to Greenville at 1:55pm. And the latest bus departs at 1:55pm.
What are the CO₂ emissions for the bus trip from Myrtle Beach to Greenville?
A bus trip from Myrtle Beach to Greenville generates an estimated 8 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Myrtle Beach to Greenville, SC was searched and found on Feb 2, 2026 with a price of $109To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Myrtle Beach to Greenville, SC, as early as possible.
You can expect to pay from $109 to $135 for a bus ticket from Myrtle Beach to Greenville, SC based on the last 2 days. You can expect to find the cheapest price for the trip at $109 which is on 2026-02-02.
Top traveled bus routes
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Popular bus departures from Myrtle Beach
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