Next departures for Orlando to Durham on November 20
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Bus
Orlando Bus Station
Durham Greyhound Bus Station
CheapestFastest
Bus
Orlando Bus Station
Durham Greyhound Bus Station
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FlixBus + Greyhound Lines, Inc.
Bus
Orlando Bus Station
Durham Greyhound Bus Station
No tags
Bus
Orlando Bus Station
Durham Greyhound Bus Station
No tags
Bus
Orlando Bus Station
Durham Greyhound Bus Station
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Last refresh of the prices: Today at 9:27 AM EST.
Compare 2 ways to go from Orlando to Durham
We recommend taking the train
Among the sustainable travel choices, the train stands out as the good way to reach Durham. The journey takes about 15 hours 40 minutes and with fares starting at just $67, it presents an excellent value for a comfortable ride.
Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
E Main St at Roxboro St (WB), Durham, NC 27701, USA
Frequently asked questions about traveling from Orlando to Durham, NC, US by bus
How far is Orlando from Durham?
Orlando and Durham are 535 miles (863 km) apart.
What are the departure and arrival stations when taking the bus from Orlando to Durham?
Most of the buses traveling from Orlando to Durham leave from Orlando Bus Station and arrive at Durham Greyhound Bus Station. These are the most popular departure and arrival locations on this route, but you can find others that could fit better into your travel plans.
What are the best sights and things to do in Durham?
Once in Durham, you can start exploring the city and discover its surroundings. The top sights and things to do are Crook Hall, High Force Waterfall, Durham Castle, Oriental Museum and HMS Trincomalee Trust.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
11/17
$148
11/18
$173
Today
$89
11/20
$134
11/21
$96
11/22
No data
11/23
$91
11/24
No data
The cheapest trip from Orlando to Durham, NC, US was searched and found on Nov 19, 2025 with a price of $89
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Orlando to Durham, NC, US, as early as possible.
You can expect to pay from $89 to $194 for a bus ticket from Orlando to Durham, NC, US based on the last 2 days. You can expect to find the cheapest price for the trip at $91 which is on 2025-11-23.
Usually Greyhound will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
The cheapest trip from Orlando to Durham, NC, US was searched and found on Nov 19, 2025 with a price of $89
