Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Greyhound Portland San Francisco recent customer reviews
This was the worst bus journey of my entire life. After the first bus driver didn't turn up our 2hr delay meant we missed our connection which was not held for us. Then after 5 hours in a bus station where another driver didn't turn up and apparently snow in San fransisco indefinitely delayed our bus we had to give up and rent a car to catch our flight on time. Sufficed to say when we arrived in San fransisco there was no sign of snow. In less time than this one failed bus journey I'd flown halfway around the globe. Ever since I've met many people with similar horror stories about Greyhound. Do not use them!
Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.
Frequently asked questions about traveling from Portland, OR to San Francisco, US by bus
How far is Portland from San Francisco?
The distance separating Portland and San Francisco is 535 miles (863 km).
What are the departure and arrival stations when taking the bus from Portland to San Francisco?
Most of the buses traveling from Portland to San Francisco leave from Portland Union Station and arrive at Hyde/Beach (Fisherman's Wharf). These are the most popular pick-up and drop-off locations on this route, but you could find others that could be a better fit for your travel plans.
What are the best sights and things to do in San Francisco?
Once in San Francisco, you can start exploring the city and discover its surroundings. The top sights and things to do are Fisherman’s Wharf, Cable Car Museum, San Francisco Zoo, Alcatraz and San Francisco Cable Cars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
11/18
$144
11/19
$153
Today
$152
11/21
$204
11/22
$169
11/23
$173
11/24
$140
11/25
$153
The cheapest trip from Portland, OR to San Francisco, US was searched and found on Nov 24, 2025 with a price of $140
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Portland, OR to San Francisco, US, as early as possible.
You can expect to pay from $140 to $204 for a bus ticket from Portland, OR to San Francisco, US based on the last 2 days. You can expect to find the cheapest price for the trip at $140 which is on 2025-11-24.
The cheapest trip from Portland, OR to San Francisco, US was searched and found on Nov 24, 2025 with a price of $140
