What is the travel distance from Puerto Iguazú to Santa Fe?

About 558 miles (900 km) separate Puerto Iguazú and Santa Fe.

What are the departure and arrival stations when taking the bus from Puerto Iguazú to Santa Fe?

The majority of buses traveling from Puerto Iguazú to Santa Fe start their journey at Terminal de Ómnibus and wind up at Estación Terminal de Ómnibius, Santa Fe. These are the main departure and arrival locations on this route, but you can find others that could fit better into your travel plans.

What are the best sights and things to do in Santa Fe?

Once in Santa Fe, you can start exploring the city and discover its surroundings. The top sights and things to do are Fiestas de Santa Fe, Native American Pueblos, St. Francis Cathedral, Aspen Santa Fe Ballet and Santa Fe Opera House.

Bus Puerto Iguazú to Santa Fe from $62 | Refundable Tickets

Next bus departures

Next departures for Puerto Iguazú to Santa Fe on November 20
Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Bus	4:00pm	Terminal de Ómnibus	16h 20m	8:20am	Estación Terminal de Ómnibius, Santa Fe	Cheapest
Bus	2:00pm	Terminal de Ómnibus	16h	6:00am	Estación Terminal de Ómnibius, Santa Fe	Fastest
Bus	7:30am	Terminal de Ómnibus	17h 30m	1:00am	Estación Terminal de Ómnibius, Santa Fe	No tags
Bus	7:30am	Terminal de Ómnibus	17h 30m	1:00am	Estación Terminal de Ómnibius, Santa Fe	No tags
Bus	12:00pm	Terminal de Ómnibus	16h 45m	4:45am	Estación Terminal de Ómnibius, Santa Fe	No tags

Last refresh of the prices: Last Monday at 3:45 PM -03.

Get from Puerto Iguazú to Santa Fe

This route is served by bus only

The journey takes about 16 hours 45 minutes and with fares starting at just $65, it presents an excellent value for a comfortable ride.

4bus per day

16h 45mAverage Duration

558 milesDistance

22kgCO₂ emissions

Compare bus companies

Rio Uruguay

4/5571 reviews

Staff4.5

Timeliness3.7

Cleanliness4

Wifi0.4

20 de Junio

4/5585 reviews

Staff4.8

Timeliness4.1

Cleanliness4.5

Wifi2.3

Expreso Singer

3/5261 reviews

Staff3.9

Timeliness2.9

Cleanliness3.2

Wifi0.7

AR bus companies: FlixBus, BlaBlaCar Bus, ALSA, Greyhound, Intercape, Trenitalia, Sindbad

Where are the popular stops in Puerto Iguazú and Santa Fe?

Stops in Puerto Iguazú

A - Terminal de Ómnibus

B - Puerto Iguazú Accesso

Stops in Santa Fe

A - Estación Terminal de Ómnibius, Santa Fe

Frequently asked questions about traveling from Puerto Iguazú to Santa Fe, AR by bus

What is the travel distance from Puerto Iguazú to Santa Fe?
What are the departure and arrival stations when taking the bus from Puerto Iguazú to Santa Fe?
What are the best sights and things to do in Santa Fe?

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

11/17

$62

11/18

$63

Today

$63

11/20

$71

11/21

$71

11/22

$72

11/23

$71

11/24

$72

The cheapest trip from Puerto Iguazú to Santa Fe, AR was searched and found on Nov 17, 2025 with a price of $62

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Puerto Iguazú to Santa Fe, AR, as early as possible.

You can expect to pay from $62 to $90 for a bus ticket from Puerto Iguazú to Santa Fe, AR based on the last 2 days. You can expect to find the cheapest price for the trip at $71 which is on 2025-11-23.

Usually Rio Uruguay will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.