Previously seen trips
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Santander (Estacion de Autobuses) | Prague (Main Station - parking) | No tags | ||||
| Bus | Santander (Estacion de Autobuses) | Prague (Central Bus Station Florenc) | No tags | ||||
| Bus | Santander (Estacion de Autobuses) | Prague (Main Railway Station) | No tags | ||||
| Bus | Santander (Estacion de Autobuses) | Prague (Main Railway Station) | No tags | ||||
| Bus | Santander (Estacion de Autobuses) | Holešovice | No tags |
Get from Santander to Prague
The journey takes about 1 day, 12 hours 50 minutes and with fares starting at just $115, it presents an excellent value for a comfortable ride.
Where are the popular stops in Santander and Prague?
Stops in Santander
- ACalle Navas de Tolosa, 2, 39002 Santander, Cantabria, Spain
- C
Av. de los Castros 43A
Av. de los Castros 43A, 39005 Santander, Cantabria, Spain - D
Calle Camarreal-Ojaiz
Calle Camarreal-Ojaiz, 52, 39011 Santander, Cantabria, Spain - E
Av. de Pontejos
Av. de Pontejos, 33A, 39005 Santander, Cantabria, Spain - F
Estación Marítima
39002 Santander, Cantabria, Spain
Stops in Prague
- A
Zličín
Drahoňovského, 163 00 Praha 17, Czech Republic - BTomíčkova 2234, Chodov, 148 00 Praha-Praha 11, Czechia
- CAviatická, 161 08, Praha 6, Czechia
- DKřižíkova 2b, Nové Město, 186 00 Praha-Praha 8, Czech Republic
- EChlumecká, 198 00 Praha 20, Czech Republic
- F300/8 Wilsonova, 110 00 Praha, Czechia
Compare bus companies
Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.
Frequently asked questions about traveling from Santander to Prague by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Santander to Prague?
The cheapest bus tickets from Santander to Prague start from $115. The average price for this route is around $127. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Santander to Prague?
The average bus trip duration from Santander to Prague is 1d 12h, covering a distance of 972 miles (1568 km). The quickest bus can get you there in 1d 12h and is operated by FlixBus.
Which bus companies service the Santander to Prague route?
Several major train operators operate on this route with 6 trains available per day.
What is the earliest and latest departure time for the bus from Santander to Prague?
The earliest bus departs from Santander to Prague at 6:50pm. And the latest bus departs at 6:50pm.
What are the CO₂ emissions for the bus trip from Santander to Prague?
A bus trip from Santander to Prague generates an estimated 39 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Santander to Prague was searched and found on Jan 14, 2026 with a price of $111To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Santander to Prague, as early as possible.
You can expect to pay from $111 to $127 for a bus ticket from Santander to Prague based on the last 2 days. You can expect to find the cheapest price for the trip at $111 which is on 2026-01-14.
