Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Tupelo (Brothers Quick Stop) | BILOXI | CheapestFastest | ||||
| Bus | Tupelo (Brothers Quick Stop) | BILOXI | No tags |
Last refresh of the prices: Last Friday at 11:14 AM CST.
Get from Tupelo to Biloxi
The journey takes about 15 hours 45 minutes and with fares starting at just $127, it presents an excellent value for a comfortable ride.
Compare bus companies
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Frequently asked questions about traveling from Tupelo to Biloxi by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Tupelo to Biloxi?
The cheapest bus tickets from Tupelo to Biloxi start from $127. The average price for this route is around $147. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Tupelo to Biloxi?
The average bus trip duration from Tupelo to Biloxi is 15h 45m, covering a distance of 265 miles (428 km). The quickest bus can get you there in 15h 45m and is operated by Greyhound.
Which bus companies service the Tupelo to Biloxi route?
Several major train operators operate on this route with 2 trains available per day.
What is the earliest and latest departure time for the bus from Tupelo to Biloxi?
The earliest bus departs from Tupelo to Biloxi at 10:55am. And the latest bus departs at 11:15pm.
What are the CO₂ emissions for the bus trip from Tupelo to Biloxi?
A bus trip from Tupelo to Biloxi generates an estimated 11 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Tupelo to Biloxi was searched and found on Dec 23, 2025 with a price of $145To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Tupelo to Biloxi, as early as possible.
You can expect to pay from $145 to $246 for a bus ticket from Tupelo to Biloxi based on the last 2 days. You can expect to find the cheapest price for the trip at $145 which is on 2025-12-23.
