Next train departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Train | Depew Station | Chicago (Union Station), IL | Cheapest | ||||
| Train | Depew Station | Chicago (Union Station), IL | Fastest |
Last refresh of the prices: Today at 9:39 AM EDT.
Compare 2 ways to go from Buffalo to Chicago
Among the sustainable travel choices, the Bus stands out as a good way to reach Chicago. The journey takes about 16 hours 40 minutes and with fares starting at just $62, it presents an excellent value for a comfortable ride.
Where are the popular train stations and stops in Buffalo, NY and Chicago?
Chicago
- A
Union Station
225 S Canal St, Chicago, IL 60606, USA
Train Companies
Based on 5767 reviews, the company was rated 4.1 stars on Busbud. Travelers were especially satisfied with the seats and the ticket access but often complained with the wifi. Amtrak ticket prices on this trip start at $56
Frequently asked questions about traveling from Buffalo, NY to Chicago by train
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the train ticket from Buffalo to Chicago?
The cheapest train tickets from Buffalo to Chicago start from $56. The average price for this train route is around $77. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the train journey from Buffalo to Chicago?
The average train ride duration from Buffalo to Chicago is 10h 33m, covering a distance of 460 miles (741 km). The quickest train can get you there in 10h 33m and is operated by Amtrak.
Which train operators service the Buffalo to Chicago route?
Several major train operators operate on this route with 1 trains available per day.
What is the earliest and latest departure time for the train from Buffalo to Chicago?
The earliest train departs from Buffalo to Chicago at 12:39am. And the latest train departs at 12:39am.
Find cheapest prices for trains
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Buffalo, NY to Chicago was searched and found on Mar 17, 2026 with a price of $129To save money and be sure you have the best seat, it's a good idea to buy your train tickets from Buffalo, NY to Chicago, as early as possible.
You can expect to pay from $129 to $1,099 for a train ticket from Buffalo, NY to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at $129 which is on 2026-03-17.
What's the cheapest way to go from Buffalo, NY to Chicago?
The Train is the cheapest travel choice for this destinationThe best way to travel between Buffalo, NY and Chicago is by train. By choosing the train, you'll get to save some money as you travel to your destination, as ticket prices cost $77 on average. If you're on a budget, you'll find cheap tickets from $56. If you're looking for the fastest way to get to Chicago, choose the train, as it will take you from Buffalo, NY to Chicago in about 10h 33m - that's the fastest way to get there!
