Next departures for Buffalo to Chicago on November 20
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Niagara Frontier Transportation Authority
Downtown Greyhound Station
CheapestFastest
Bus
Niagara Frontier Transportation Authority
537-517 W. Jackson Blvd
No tags
Bus
Niagara Frontier Transportation Authority
Chicago 95Th & Dan Ryan
No tags
Next departures for Buffalo to Chicago on November 21
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Niagara Frontier Transportation Authority
Downtown Greyhound Station
CheapestFastest
Bus
Niagara Frontier Transportation Authority
537-517 W. Jackson Blvd
No tags
Bus
Niagara Frontier Transportation Authority
Chicago 95Th & Dan Ryan
No tags
Next departures for Buffalo to Chicago on November 23
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Niagara Frontier Transportation Authority
537-517 W. Jackson Blvd
Cheapest
Bus
Niagara Frontier Transportation Authority
Downtown Greyhound Station
Fastest
Bus
Niagara Frontier Transportation Authority
Chicago 95Th & Dan Ryan
No tags
Last refresh of the prices: Today at 9:15 AM EST.
Compare 2 ways to go from Buffalo to Chicago
We recommend taking the bus
Among the sustainable travel choices, the bus stands out as the good way to reach Chicago. The journey takes about 15 hours 30 minutes and with fares starting at just $56, it presents an excellent value for a comfortable ride.
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Greyhound Buffalo Chicago recent customer reviews
Very unhappy with our travel from Buffalo to Chicago. The bus from buffalo to cleavelent was an hour late which was not the the biggest drama however the problem was that the greyhound bus station in both buffalo and cleavelend was very miserable, cold, dirty and smelly and most of all looking very unsafe. The whole experience really made us not want to travel with a bus anymore in our life.
1 out of 5 stars
Pamela D.
Before was good but yesterday i was shocked because i could not move back of my seat .most of the seat greyhound should fixed
2 out of 5 stars
Mostafa S.
I am dissatisfied with the services of Greyhound. Unsystematic and slow work.
Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.
Frequently asked questions about traveling from Buffalo, NY to Chicago by bus
What is the travel distance from Buffalo to Chicago?
About 453 miles (731 km) separate Buffalo and Chicago.
What are the departure and arrival stations when taking the bus from Buffalo to Chicago?
The majority of buses traveling from Buffalo to Chicago start their journey at Buffalo Airport and wind up at Downtown Greyhound Station. These are the main departure and arrival locations on this route, but you can find others that could fit better into your travel plans.
What are the best sights and things to do in Chicago?
Once in Chicago, you can start exploring the city and discover its surroundings. The top sights and things to do are Cloud Gate, Architectural River Cruise, Museum of Science and Industry, Brookfield Zoo and Chicago Shakespeare Theater on Navy Pier.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
11/17
$94
11/18
$97
Today
$97
11/20
$103
11/21
$112
11/22
$81
11/23
$106
11/24
$71
The cheapest trip from Buffalo, NY to Chicago was searched and found on Nov 24, 2025 with a price of $71
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Buffalo, NY to Chicago, as early as possible.
You can expect to pay from $71 to $231 for a bus ticket from Buffalo, NY to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at $71 which is on 2025-11-24.
What's the cheapest way to go from Buffalo, NY to Chicago?
The bus is the cheapest travel choice for this destination
The cheapest trip from Buffalo, NY to Chicago was searched and found on Nov 24, 2025 with a price of $71
The bus is the cheapest travel choice for this destination
