Find coaches from La Serena, CL to Antofagasta

Find affordable coach tickets from La Serena, CL to Antofagasta with flexible options. Book your journey now

Join 75M+ travellers booking 2M+ routes across 85+ countries.
Enjoy our 24/7 customer service to assist you at every stage.
Cancel anytime and receive a 100% refund, no reason needed.
Today16 Jul
from US$21
Tomorrow17 Jul
from US$21
Fri18 Jul
from US$21
Sat19 Jul
from US$21
Sun20 Jul
from US$35
Mon21 Jul
Tue22 Jul
from US$27
Wed23 Jul

Cheap buses leaving tomorrow

One passenger / one way

  • This trip is recommended because it is the: Cheapest
    Departure time: 17 July at
    Departure city: La Serena
    Departure location: Terminal de Buses La Serena
    Arrival time: 18 July at
    Destination city: Antofagasta
    Destination location: Terminal Antofagasta
    Operated by: Cikbus ElitéCikbus Elité
    Vehicle: BusDuration:
  • This trip is recommended because it is the: Fastest
    Departure time: 17 July at
    Departure city: La Serena
    Departure location: Terminal de Buses La Serena
    Arrival time: 18 July at
    Destination city: Antofagasta
    Destination location: Terminal Antofagasta
    Operated by: Cikbus ElitéCikbus Elité
    Vehicle: BusDuration:
  • Departure time: 17 July at
    Departure city: La Serena
    Departure location: Terminal de Buses La Serena
    Arrival time: 17 July at
    Destination city: Antofagasta
    Destination location: Terminal Antofagasta
    Operated by: Cikbus ElitéCikbus Elité
    Vehicle: BusDuration:
  • Departure time: 17 July at
    Departure city: La Serena
    Departure location: Terminal de Buses La Serena
    Arrival time: 18 July at
    Destination city: Antofagasta
    Destination location: Terminal Antofagasta
    Operated by: Pluss ChilePluss Chile
    Vehicle: BusDuration:
  • Departure time: 17 July at
    Departure city: La Serena
    Departure location: Terminal de Buses La Serena
    Arrival time: 18 July at
    Destination city: Antofagasta
    Destination location: 5791 Avenida Iquique
    Operated by: AndimarAndimar
    Vehicle: BusDuration:

Accepted payments

  • Visa
  • MasterCard
  • American Express
  • China Union Pay
  • Diners Club Canada
  • Discover Click to Pay
  • JCB payment
  • Klarna (Pay over time)
  • Google Pay

Bus La Serena to Antofagasta: Trip Overview

Average ticket priceUS$41
Average bus trip duration11h 35m
Number of daily buses28
Earliest bus departure00:05
Distance438 miles
Latest bus departure23:59

La Serena to Antofagasta Bus

Busbud helps you find a bus from La Serena to Antofagasta. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

Bus service from La Serena to Antofagasta will be provided by the most trusted bus companies.

Whether it is cheap bus tickets or more luxurious buses going to Antofagasta from La Serena, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions on the trip La Serena, CL - Antofagasta

  1. What's the distance between La Serena and Antofagasta by coach?

    The distance between La Serena and Antofagasta by coach is approximately 437 miles (704 km).

  2. How can I travel from La Serena to Antofagasta avoiding air travel?

    You have the option to select the coach for your journey on this route. The coach ensures a pleasant travel experience, granting you the opportunity to appreciate the scenery as you make your way to your final stop. You might also find carpooling options to travel between the two cities.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
14/07
US$32
15/07
US$19
Today
US$19
17/07
US$19
18/07
US$19
19/07
US$19
20/07
US$32
21/07
US$33
busbud logoThe cheapest trip from La Serena to Antofagasta was searched and found on 17 Jul 2025 with a price of US$19

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from La Serena to Antofagasta as early as possible.

You can expect to pay from US$19 to US$52 for a bus ticket from La Serena to Antofagasta based on the last 2 days. You can expect to find the cheapest price for the trip at US$19, which is on 2025-07-17.

Usually PlussChile, Pullman San Andrés will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between La Serena and Antofagasta!

Much more than a mere vehicle taking you from La Serena to Antofagasta, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from La Serena to Antofagasta.

Make a music playlist for your bus ride from La Serena to Antofagasta, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

Will you be returning to La Serena by bus?

Bus from La Serena to Antofagasta

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud makes bus travel easy. We help travellers find a bus, plot routes, and book intercity bus tickets all over the world. Use Busbud to book your trip online, in your own language and currency, wherever you are. Busbud prides itself on its worldwide partnerships. We make it possible for you to buy tickets with its large network of trustworthy bus partners like Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

People from around the world trust Busbud

‌

Popular Buses Connecting La Serena

Buses Leaving from La Serena

Buses Going to La Serena

Popular Buses Connecting Antofagasta

Buses Leaving from Antofagasta

Buses Going to Antofagasta