Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Orlando Bus Station | Bus station | Cheapest | ||||
| Bus | Orlando Bus Station | Florence, SC | Fastest | ||||
| Bus | Orlando Bus Station | Bus station | No tags | ||||
| Bus | The Florida Mall | Florence, SC | No tags |
Last refresh of the prices: Today at 8:00 AM EST.
Compare 2 ways to go from Orlando to Florence
Among the sustainable travel choices, the bus stands out as a good way to reach Florence. The journey takes about 9 hours 35 minutes, and with fares starting at just $83, it presents an excellent value for a comfortable ride.
Compare bus companies
Where are the popular stops in Orlando and Florence?
Frequently asked questions about travelling from Orlando to Florence, SC, US by bus
How far is Orlando from Florence?
It's about 653 km (405 miles) from Orlando to Florence.
What are the departure and arrival locations for buses traveling from Orlando to Florence?
Buses departing from Orlando Bus Station in Orlando will take you to Florence Bus Station in Florence.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Orlando to Florence, SC, US was searched and found on Nov 17, 2025 with a price of $121To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Orlando to Florence, SC, US, as early as possible.
You can expect to pay from $121 to $245 for a bus ticket from Orlando to Florence, SC, US based on the last 2 days. You can expect to find the cheapest price for the trip at $121 which is on 2025-11-24.
What's the cheapest way to go from Orlando to Florence, SC, US?
The bus is the cheapest travel choice for this destination
