Next bus departures

Next departures for Orlando to Florence on October 18
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended	Price and booking link
FlixBus + Greyhound Lines, Inc.	Bus Wifi Toilet Power outlets	9:55pm	Orlando Bus Station	15h 35m	1:30pm	Bus station	CheapestFastest

Last refresh of the prices: Last Friday at 5:46 PM EDT.

Compare 2 ways to go from Orlando to Florence

We recommend taking the train

Among the sustainable travel choices, the Train stands out as a good way to reach Florence. The journey takes about 9 hours 46 minutes and with fares starting at just $72, it presents an excellent value for a comfortable ride.

1train per day

9h 46mAverage Duration

403 milesDistance

59kgCO₂ emissions

	Average Price	Average Duration	CO₂ emissions	Actions
Bus	Average Price$61 - $197	Average Duration16h 40m	CO₂ emissions 16kg CO₂e
Train	Average Price$72 - $185	Average Duration9h 46m	CO₂ emissions 59kg CO₂e

Bus stations and stops in Orlando and Florence

Stops in Orlando

A
Orlando Bus Station
555 N John Young Pkwy, Orlando, FL 32805
Visit page
B
Orlando RedCoach Station
RedCoach Station, 1777 McCoy Road, Orlando, FL 32809
Visit page
C
Jet Set Express Terminal
Jet Set Express Terminal, 3718 LB Mcleod Rd., 32805 Orlando, FL,, United States
Visit page
D
Disney World
Disney's All-Star Sports Resort, 1701 West Buena Vista Dr., Orlando, FL 32830
E
International Dr SuperTours Terminal
5419 International Dr, Orlando, FL 32819, USA
F
Seaworld Hotels
10100 International Drive , Orlando, 32821

Stops in Florence

A
Florence Bus Station
619 S Irby St, Florence, SC 29501, USA
Visit page
B
TA Travel Center - Florence
2301 W Lucas St, Florence, SC 29501, USA

Compare bus companies

FlixBus

3.5/516,294 reviews

Staff4.2

Timeliness4.0

Cleanliness4.1

Wifi2.7

Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.

Greyhound

3.5/588,240 reviews

Staff3.6

Timeliness3.0

Cleanliness3.4

Wifi2.5

Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.

US bus companies:FlixBus, Greyhound, Tufesa, Chihuahuenses, Adirondack Trailways, Valley Transit, Wanda Coach

Frequently asked questions about traveling from Orlando to Florence, SC, US by bus

Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.

How much is the bus ticket from Orlando to Florence?
The cheapest bus tickets from Orlando to Florence start from $61. The average price for this route is around $98. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Orlando to Florence?
The average bus trip duration from Orlando to Florence is 16h 40m, covering a distance of 403 miles (650 km). The quickest bus can get you there in 8h 25m and is operated by FlixBus.
Which bus companies service the Orlando to Florence route?
Several major bus companies operate on this route with 8 buses available per day, including services from FlixBus, Greyhound.
What is the earliest and latest departure time for the bus from Orlando to Florence?
The earliest bus departs from Orlando to Florence at 6:00am. And the latest bus departs at 10:55pm.
What are the CO₂ emissions for the bus trip from Orlando to Florence?
A bus trip from Orlando to Florence generates an estimated 16.2369 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
What is the best bus company from Orlando to Florence?
According to Busbud customers, the highest-rated bus company on this route is FlixBus, with an average rating of 3.5 out of 5 stars based on 16115 reviews.
Which bus company has the best Wi-Fi from Orlando to Florence?
Based on reviews on Busbud, the bus company FlixBus has the best Wi-Fi rating with a score of 2.7.
Which bus company has the most timely service from Orlando to Florence?
According to Busbud traveler reviews, the most timely bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Orlando to Florence?
According to Busbud traveler reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

10/16

$66

10/17

$82

Today

$107

10/19

$62

10/20

No data

10/21

No data

10/22

$58

10/23

$60

The cheapest trip from Orlando to Florence, SC, US was searched and found on Oct 22, 2026 with a price of $58

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Orlando to Florence, SC, US, as early as possible.

You can expect to pay from $58 to $157 for a bus ticket from Orlando to Florence, SC, US based on the last 2 days. You can expect to find the cheapest price for the trip at $58 which is on 2026-10-22.