Bus Tickets from Philadelphia, PA to Florence, SC, US

Next departures

Next departures for Philadelphia to Florence on October 6
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
FlixBus + Greyhound Lines, Inc.
Philadelphia, 199 Spring Garden St
Bus stationCheapest
Greyhound Lines, Inc. + FlixBus
199 Spring Garden St.
Bus stationFastest
FlixBus + Greyhound Lines, Inc.
Cherry Hill Mall
Bus stationNo tags
FlixBus + Greyhound Lines, Inc.
Philadelphia (Logan Square)
Bus stationNo tags
Greyhound Lines, Inc. + FlixBus
Schuylkill & Walnut
Bus stationNo tags

Last refresh of the prices: Yesterday at 7:34 AM EDT.

Accepted payments

  • Visa
  • MasterCard
  • American Express
  • China Union Pay
  • Diners Club Canada
  • Discover Click to Pay
  • JCB payment
  • Klarna (Pay over time)
  • Google Pay

Compare 2 ways to go from Philadelphia to Florence

Bus
Average PriceUS$53 - US$145Average Duration16h 45m
19kg CO₂e5 out of 5 stars
CheapestMost eco-friendly
Train
Average PriceUS$91 - US$312Average Duration10h 22m
69kg CO₂e1 out of 5 stars
Fastest
busbud logoBusbud recommends taking the train from Philadelphia to Florence

Among the sustainable travel choices, the train stands out as a good way to reach Florence. The journey takes about 10 hours 22 minutes, and with fares starting at just US$91, it presents an excellent value for a comfortable ride.

2train per day
10h 22mAverage Duration
US$91Cheapest ticket
69kgCO₂ emissions

Bus Philadelphia, PA to Florence, SC, US: Trip Overview

Average Ticket PriceUS$78
Average Bus Trip Duration16h 45m
Number of daily buses8
Earliest bus departure10:20am
Distance766 km
Latest bus departure11:15pm

Philadelphia to Florence Bus

Busbud helps you find a bus from Philadelphia to Florence. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

We make it our job to connect you with the most dependable bus companies that cover bus service from Philadelphia to Florence.

Discover how much the bus trip from Philadelphia to Florence will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions on the trip Philadelphia, PA - Florence, SC, US

  1. What is the travel distance from Philadelphia to Florence?

    The distance between Philadelphia and Florence is around 753 km (467 miles).

  2. What are the departure and arrival locations for buses traveling from Philadelphia to Florence?

    Buses traveling this route start their trip at Philadelphia Airport, in Philadelphia, and end it at Florence Bus Station, in Florence.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
10-03
US$74
10-04
US$89
Today
US$115
10-06
No data
10-07
No data
10-08
US$93
10-09
US$66
10-10
US$98
busbud logoThe cheapest trip from Philadelphia, PA to Florence, SC, US was searched and found on Oct 9, 2025 with a price of US$66

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Philadelphia, PA to Florence, SC, US, as early as possible.

You can expect to pay from US$66 to US$124 for a bus ticket from Philadelphia, PA to Florence, SC, US based on the last 2 days. You can expect to find the cheapest price for the trip at US$66 which is on 2025-10-09.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Philadelphia and Florence!

From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from Philadelphia to Florence.

Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from Philadelphia to Florence will emit less CO2 than a car or an airplane.

Tune out to the fine sounds of your best music playlist on your bus trip from Philadelphia to Florence while indulging in miles on end of beautiful scenic views.

Did you know?

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!

What's the cheapest way to go from Philadelphia, PA to Florence, SC, US?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to Philadelphia, PA by bus?

Bus from Florence, SC, US to Philadelphia, PA

You can also go to Florence, SC, US by train

Train from Philadelphia, PA to Florence, SC, US

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud helps you easily search, compare and book intercity bus tickets on a worlwide scale with our comprehensive list of bus routes and schedules. With Busbud, wherever you go, you have a worldwide bus station within reach and available in your own language and currency. Busbud prides itself on its worldwide partnerships. We make it possible for you to buy tickets with its large network of trustworthy bus partners like Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

People from around the world trust Busbud

‌

Popular Buses Connecting Philadelphia

Buses Leaving from Philadelphia

Buses Going to Philadelphia

Popular Buses Connecting Florence

Buses Leaving from Florence

Buses Going to Florence