What is the travel distance from Philadelphia to Florence?

The distance between Philadelphia and Florence is around 753 km (467 miles).

What are the departure and arrival locations for buses traveling from Philadelphia to Florence?

Buses traveling this route start their trip at Philadelphia Airport, in Philadelphia, and end it at Florence Bus Station, in Florence.

Bus Philadelphia to Florence from $92 | Refundable Tickets

Next bus departures

Next departures for Philadelphia to Florence on November 19
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
	Bus	8:30pm	199 Spring Garden St.	15h 15m	11:45am	Bus station	Cheapest
	Bus	6:30pm	Philadelphia, 199 Spring Garden St	11h 15m	5:45am	Florence, SC	Fastest
Greyhound Lines, Inc. + FlixBus	Bus	5:50pm	199 Spring Garden St.	11h 55m	5:45am	Florence, SC	No tags
	Bus	8:00pm	Schuylkill & Walnut	15h 45m	11:45am	Bus station	No tags
FlixBus + Greyhound Lines, Inc.	Bus	6:45pm	Philadelphia, 199 Spring Garden St	17h	11:45am	Bus station	No tags

Next departures for Philadelphia to Florence on November 20
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Greyhound Lines, Inc. + FlixBus	Bus	1:25pm	Schuylkill & Walnut	16h 20m	5:45am	Florence, SC	Cheapest
	Bus	6:30pm	Philadelphia, 199 Spring Garden St	11h 15m	5:45am	Florence, SC	Fastest
	Bus	8:30pm	199 Spring Garden St.	15h 15m	11:45am	Bus station	No tags
Greyhound Lines, Inc. + FlixBus	Bus	5:50pm	199 Spring Garden St.	11h 55m	5:45am	Florence, SC	No tags
	Bus	11:00am	Cherry Hill Mall	18h 45m	5:45am	Florence, SC	No tags

Next departures for Philadelphia to Florence on November 21
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
FlixBus + Greyhound Lines, Inc.	Bus	10:00pm	Philadelphia, 199 Spring Garden St	13h 45m	11:45am	Bus station	Cheapest
	Bus	6:30pm	Philadelphia, 199 Spring Garden St	11h 15m	5:45am	Florence, SC	Fastest
	Bus	8:30pm	199 Spring Garden St.	15h 15m	11:45am	Bus station	No tags
Greyhound Lines, Inc. + FlixBus	Bus	5:50pm	199 Spring Garden St.	11h 55m	5:45am	Florence, SC	No tags
	Bus	11:00am	Cherry Hill Mall	18h 45m	5:45am	Florence, SC	No tags

Next departures for Philadelphia to Florence on November 22
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
FlixBus + Greyhound Lines, Inc.	Bus	10:00pm	Philadelphia, 199 Spring Garden St	13h 45m	11:45am	Bus station	Cheapest
	Bus	6:30pm	Philadelphia, 199 Spring Garden St	11h 15m	5:45am	Florence, SC	Fastest
	Bus	8:30pm	199 Spring Garden St.	15h 15m	11:45am	Bus station	No tags
Greyhound Lines, Inc. + FlixBus	Bus	5:50pm	199 Spring Garden St.	11h 55m	5:45am	Florence, SC	No tags
	Bus	11:00am	Cherry Hill Mall	18h 45m	5:45am	Florence, SC	No tags

Next departures for Philadelphia to Florence on November 23
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
FlixBus + Greyhound Lines, Inc.	Bus	10:00pm	Philadelphia, 199 Spring Garden St	13h 45m	11:45am	Bus station	Cheapest
	Bus	6:30pm	Philadelphia, 199 Spring Garden St	11h 15m	5:45am	Florence, SC	Fastest
	Bus	8:30pm	199 Spring Garden St.	15h 15m	11:45am	Bus station	No tags
Greyhound Lines, Inc. + FlixBus	Bus	5:50pm	199 Spring Garden St.	11h 55m	5:45am	Florence, SC	No tags
	Bus	11:00am	Cherry Hill Mall	18h 45m	5:45am	Florence, SC	No tags

Next departures for Philadelphia to Florence on November 24
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
FlixBus + Greyhound Lines, Inc.	Bus	10:00pm	Philadelphia, 199 Spring Garden St	13h 45m	11:45am	Bus station	Cheapest
	Bus	6:30pm	Philadelphia, 199 Spring Garden St	11h 15m	5:45am	Florence, SC	Fastest
	Bus	8:30pm	199 Spring Garden St.	15h 15m	11:45am	Bus station	No tags
Greyhound Lines, Inc. + FlixBus	Bus	5:50pm	199 Spring Garden St.	11h 55m	5:45am	Florence, SC	No tags
	Bus	11:00am	Cherry Hill Mall	18h 45m	5:45am	Florence, SC	No tags

Last refresh of the prices: Yesterday at 8:43 AM EST.

Compare 2 ways to go from Philadelphia to Florence

We recommend taking the train

Among the sustainable travel choices, the train stands out as a good way to reach Florence. The journey takes about 10 hours 22 minutes, and with fares starting at just $130, it presents an excellent value for a comfortable ride.

2train per day

10h 22mAverage Duration

758 kmDistance

69kgCO₂ emissions

	Average Price	Average Duration	CO₂ emissions	Actions
Bus	Average Price$85 - $342	Average Duration16h 5m	CO₂ emissions 19kg CO₂e
Train	Average Price$130 - $1,828	Average Duration10h 22m	CO₂ emissions 69kg CO₂e

Compare bus companies

Greyhound

3.5/587,382 reviews

Staff3.6

Timeliness2.9

Cleanliness3.3

Wifi2.4

FlixBus

3.5/511,376 reviews

Staff4.2

Timeliness3.9

Cleanliness4.1

Wifi2.7

US Bus Companies: FlixBus, BlaBlaCar Bus, ALSA, Greyhound, Intercape, Trenitalia, Sindbad

Where are the popular stops in Philadelphia and Florence?

Stops in Philadelphia

A - Philadelphia Airport

B - Independence Travel Center

C - #2842 St.Vincent St

D - Bus Station

E - Island Av & Suffolk Av MBFS

F - NRG SEPTA Station

Stops in Florence

A - Florence Bus Station

B - TA Travel Center - Florence

Frequently asked questions about travelling from Philadelphia, PA to Florence, SC, US by bus

What is the travel distance from Philadelphia to Florence?
The distance between Philadelphia and Florence is around 753 km (467 miles).
What are the departure and arrival locations for buses traveling from Philadelphia to Florence?
Buses traveling this route start their trip at Philadelphia Airport, in Philadelphia, and end it at Florence Bus Station, in Florence.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

11-17

$153

11-18

$183

Today

$170

11-20

$137

11-21

$175

11-22

$161

11-23

$168

11-24

$259

The cheapest trip from Philadelphia, PA to Florence, SC, US was searched and found on Nov 20, 2025 with a price of $137

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Philadelphia, PA to Florence, SC, US, as early as possible.

You can expect to pay from $137 to $301 for a bus ticket from Philadelphia, PA to Florence, SC, US based on the last 2 days. You can expect to find the cheapest price for the trip at $137 which is on 2025-11-20.

Usually FlixBus, Greyhound will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.