Bus Tickets from Buffalo (NY) to Greenville (SC)

Find affordable bus tickets from Buffalo (NY) to Greenville (SC) with flexible options. Book your trip now

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TodayJun 1
from $180
TomorrowJun 2
TueJun 3
from $131
WedJun 4
from $135
ThuJun 5
from $128
FriJun 6
SatJun 7
from $219
SunJun 8

Cheap buses leaving Tuesday

One passenger / one way

  • This trip is recommended because it is: Cheapest
    Departure time: June 3 at
    Departure city: Buffalo
    Departure location: Niagara Frontier Transportation Authority
    Arrival time: June 4 at
    Destination city: Greenville
    Destination location: 1116 Woodruff Rd
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:
  • This trip is recommended because it is: Fastest
    Departure time: June 3 at
    Departure city: Buffalo
    Departure location: Buffalo (BUF) Airport
    Arrival time: June 4 at
    Destination city: Greenville
    Destination location: 1116 Woodruff Rd
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: June 3 at
    Departure city: Buffalo
    Departure location: Niagara Frontier Transportation Authority
    Arrival time: June 4 at
    Destination city: Greenville
    Destination location: 1116 Woodruff Rd
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: June 3 at
    Departure city: Buffalo
    Departure location: Niagara Frontier Transportation Authority
    Arrival time: June 5 at
    Destination city: Greenville
    Destination location: 1116 Woodruff Rd
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:
  • Departure time: June 3 at
    Departure city: Buffalo
    Departure location: Buffalo (BUF) Airport
    Arrival time: June 4 at
    Destination city: Greenville
    Destination location: 1116 Woodruff Rd
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:

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Compare 2 ways to go from Buffalo to Greenville.

Bus
Average Price$107 - $266Average Duration1d 1h
24kg CO₂e5 out of 5 stars
CheapestMost eco-friendly
Train
Average Price$225 - $275Average Duration1d
86kg CO₂e1 out of 5 stars
Fastest
busbud logoBusbud recommends taking the bus from Buffalo to Greenville

Among the sustainable travel choices, the bus stands out as the good way to reach Greenville. The journey takes about 1 day, 1 hour 10 minutes and with fares starting at just $107, it presents an excellent value for a comfortable ride.

7bus per day
1d 1hAverage Duration
$107Cheapest ticket
24kgCO₂ emissions

Bus Buffalo to Greenville: Trip Overview

Average ticket price$141
Average bus trip duration1d 1h
Number of daily buses7
Earliest bus departure7:30am
Distance591 miles (953 km)
Latest bus departure11:59pm

Buffalo to Greenville Bus

Busbud helps you find a bus from Buffalo to Greenville. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

Bus service from Buffalo to Greenville will be provided by the most trusted bus companies.

From cheap bus tickets to more luxurious buses traveling from Buffalo to Greenville, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions for your trip Buffalo (NY) - Greenville (SC)

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
05/30
No data
05/31
$112
Today
$172
06/02
No data
06/03
$123
06/04
$136
06/05
$120
06/06
No data
busbud logoThe cheapest trip from Buffalo to Greenville was searched and found on May 31, 2025 with a price of $112

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Buffalo to Greenville, as early as possible.

You can expect to pay from $112 to $195 for a bus ticket from Buffalo to Greenville based on the last 2 days. You can expect to find the cheapest price for the trip at $120 which is on 2025-06-05.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Buffalo and Greenville!

Much more than a mere vehicle taking you from Buffalo to Greenville, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Buffalo to Greenville that are otherwise impossible to come by with a plane.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Buffalo to Greenville.

Did you know?

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travelers have used their electronic device on board during 2014.

9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

What's the cheapest way to go from Buffalo to Greenville?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to Buffalo by bus?

Bus from Buffalo to Greenville

You can also go to Greenville by train

Train from Buffalo to Greenville

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud.com makes it easy for you to find, compare and book city-to-city bus tickets, all over the world. We save you the extra trip to the bus station. With several language and currency options available, Busbud seeks to cater to international bus travelers no matter where they are in the world. Busbud partners with safe and reliable bus companies throughout the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others so you can buy tickets without a worry.

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