Next departures for Chicago to Buffalo on November 21
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
FlixBus + Greyhound Lines, Inc.
Bus
Chicago 95Th & Dan Ryan
Niagara Frontier Transportation Authority
CheapestFastest
FlixBus + Greyhound Lines, Inc.
Bus
Downtown Greyhound Station
Niagara Frontier Transportation Authority
No tags
Next departures for Chicago to Buffalo on November 23
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
FlixBus + Greyhound Lines, Inc.
Bus
Chicago 95Th & Dan Ryan
Niagara Frontier Transportation Authority
CheapestFastest
FlixBus + Greyhound Lines, Inc.
Bus
Downtown Greyhound Station
Niagara Frontier Transportation Authority
No tags
Next departures for Chicago to Buffalo on November 24
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
FlixBus + Greyhound Lines, Inc.
Bus
Chicago 95Th & Dan Ryan
Niagara Frontier Transportation Authority
CheapestFastest
FlixBus + Greyhound Lines, Inc.
Bus
Downtown Greyhound Station
Niagara Frontier Transportation Authority
No tags
Last refresh of the prices: Yesterday at 7:15 AM CST.
Compare 2 ways to go from Chicago to Buffalo
We recommend taking the train
Among the sustainable travel choices, the train stands out as the good way to reach Buffalo. The journey takes about 10 hours 23 minutes and with fares starting at just $56, it presents an excellent value for a comfortable ride.
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Greyhound Chicago Buffalo recent customer reviews
Friendly drivers
5 out of 5 stars
Cory L.
Not bad but everything US łatę and stations are terrible
Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.
Frequently asked questions about traveling from Chicago to Buffalo, NY by bus
How far is Chicago from Buffalo?
The distance between the two cities is 453 miles (731 km).
What are the departure and arrival stations when taking the bus from Chicago to Buffalo?
Most of the buses traveling from Chicago to Buffalo leave from Downtown Greyhound Station and arrive at Buffalo Airport. These are the primary departure and arrival locations on this route, but you can find others that could fit better into your travel plans.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
11/19
No data
11/20
No data
Today
$59
11/22
No data
11/23
No data
11/24
No data
11/25
$65
11/26
No data
The cheapest trip from Chicago to Buffalo, NY was searched and found on Nov 21, 2025 with a price of $59
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Chicago to Buffalo, NY, as early as possible.
You can expect to pay from $59 to $67 for a bus ticket from Chicago to Buffalo, NY based on the last 2 days. You can expect to find the cheapest price for the trip at $65 which is on 2025-11-25.
What's the cheapest way to go from Chicago to Buffalo, NY?
The bus is the cheapest travel choice for this destination