How far is Columbus from Greenville?

Columbus and Greenville are 355 miles (572 km) apart.

What are the departure and arrival stations when taking the bus from Columbus to Greenville?

Most of the buses traveling from Columbus to Greenville leave from Columbus Bus Station and arrive at Guadalajara Supermarket Bus Stop. These are the most popular pick-up and drop-off locations on this route, but you can also find other options that could better fit your plans.

Bus Columbus to Greenville from $118 | Refundable Tickets

Previously seen trips

Next departures for Columbus to Greenville on November 20
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Greyhound + FlixBus	Bus	9:45am	100 E Rich St	21h 50m	7:35am	1116 Woodruff Rd	No tags
Greyhound + FlixBus	Bus	10:45pm	Columbus Bus Station	21h 10m	7:55pm	1116 Woodruff Rd	No tags
	Bus	12:25am	Columbus Bus Station	14h 55m	3:20pm	1116 Woodruff Rd	No tags
	Bus	5:10am	Columbus Bus Station	1d 2h	7:35am	1116 Woodruff Rd	No tags
Greyhound + FlixBus	Bus	2:45pm	Columbus Bus Station	21h 15m	12:00pm	1116 Woodruff Rd	No tags

Get from Columbus to Greenville

This route is served by bus only

The journey takes about 21 hours 30 minutes and with fares starting at just $103, it presents an excellent value for a comfortable ride.

5bus per day

21h 30mAverage Duration

356 milesDistance

14kgCO₂ emissions

Compare bus companies

Greyhound

3.5/587,382 reviews

Staff3.6

Timeliness2.9

Cleanliness3.3

Wifi2.4

Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.

FlixBus

3.5/511,380 reviews

Staff4.2

Timeliness3.9

Cleanliness4.1

Wifi2.7

Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.

US bus companies: FlixBus, BlaBlaCar Bus, ALSA, Greyhound, Intercape, Trenitalia, Sindbad

Where are the popular stops in Columbus and Greenville?

Stops in Columbus

A - Columbus Bus Station

Stops in Greenville

A - Guadalajara Supermarket Bus Stop

B - Greenville Bus Station

Frequently asked questions about traveling from Columbus, OH to Greenville, SC by bus

How far is Columbus from Greenville?
What are the departure and arrival stations when taking the bus from Columbus to Greenville?

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

11/18

No data

11/19

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Today

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11/21

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11/22

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11/23

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11/24

$118

11/25

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The cheapest trip from Columbus, OH to Greenville, SC was searched and found on Nov 24, 2025 with a price of $118

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Columbus, OH to Greenville, SC, as early as possible.

You can expect to pay from $118 to $120 for a bus ticket from Columbus, OH to Greenville, SC based on the last 2 days. You can expect to find the cheapest price for the trip at $118 which is on 2025-11-24.