Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound Lines, Inc. + FlixBus | Bus | DENVER | Tupelo (Brothers Quick Stop) | CheapestFastest | ||||
 | Bus | DENVER | Tupelo (Brothers Quick Stop) | No tags |
Last refresh of the prices: Yesterday at 5:03 PM MST.
Get from Denver to Tupelo
The journey takes about 1 day, 2 hours 40 minutes and with fares starting at just $100, it presents an excellent value for a comfortable ride.
Compare bus companies
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Frequently asked questions about traveling from Denver to Tupelo by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Denver to Tupelo?
The cheapest bus tickets from Denver to Tupelo start from $100. The average price for this route is around $102. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Denver to Tupelo?
The average bus trip duration from Denver to Tupelo is 1d 2h, covering a distance of 974 miles (1571 km). The quickest bus can get you there in 1d 13h and is operated by Greyhound.
Which bus companies service the Denver to Tupelo route?
Several major train operators operate on this route with 2 trains available per day.
What is the earliest and latest departure time for the bus from Denver to Tupelo?
The earliest bus departs from Denver to Tupelo at 7:25pm. And the latest bus departs at 8:10pm.
What are the CO₂ emissions for the bus trip from Denver to Tupelo?
A bus trip from Denver to Tupelo generates an estimated 39 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Denver to Tupelo was searched and found on Dec 31, 2025 with a price of $183To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Denver to Tupelo, as early as possible.
You can expect to pay from $183 to $183 for a bus ticket from Denver to Tupelo based on the last 2 days. You can expect to find the cheapest price for the trip at $183 which is on 2025-12-31.
