Bus Tickets from Detroit, MI to Tupelo

Next departures

Next departures for Detroit to Tupelo on November 4
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Greyhound Lines, Inc.
    		Detroit Bus Station
    		Tupelo (Brothers Quick Stop)Cheapest
    Greyhound Lines, Inc.
      		Detroit Bus Station
      		Tupelo (Brothers Quick Stop)Fastest
      Greyhound Lines, Inc.
        		Detroit Bus Station
        		Tupelo (Brothers Quick Stop)No tags
        Greyhound Lines, Inc.
          		Detroit Bus Station
          		Tupelo (Brothers Quick Stop)No tags

          Last refresh of the prices: Yesterday at 6:50 PM EDT.

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          Get from Detroit to Tupelo

          This route is served by bus only

          The journey takes about 1 day, 40 minutes and with fares starting at just $92, it presents an excellent value for a comfortable ride.

          4bus per day
          1d Average Duration
          636 milesDistance
          26kgCO₂ emissions

          Bus Detroit, MI to Tupelo: Trip Overview

          Average ticket price$141
          Average bus trip duration1d
          Number of daily buses4
          Earliest bus departure6:40am
          Distance636 miles (1025 km)
          Latest bus departure11:25pm

          Detroit to Tupelo Bus

          With Busbud, comparing and booking tickets for a bus from Detroit to Tupelo is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

          We make sure you can find a bus service from Detroit to Tupelo from the most reliable bus companies operating this trip.

          Whether it is cheap bus tickets or more luxurious buses going to Tupelo from Detroit, we help you find what you're looking for based on how much of a budget you have.

          Frequently asked questions for your trip Detroit, MI - Tupelo

          Find cheapest prices for buses

          Price is for a one-way ticket for one passenger and based on past searches.

          Best price found
          10/30
          $116
          10/31
          $222
          Today
          $191
          11/02
          $168
          11/03
          $122
          11/04
          $124
          11/05
          No data
          11/06
          No data
          busbud logoThe cheapest trip from Detroit, MI to Tupelo was searched and found on Oct 30, 2025 with a price of $116

          To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Detroit, MI to Tupelo, as early as possible.

          You can expect to pay from $116 to $231 for a bus ticket from Detroit, MI to Tupelo based on the last 2 days. You can expect to find the cheapest price for the trip at $122 which is on 2025-11-03.

          About Bus Travel

          Bus Travel Tips

          Meet and talk to locals at the bus stations while traveling from Detroit to Tupelo.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

          Start sightseeing the minute your bus leaves the station. If you're on the night bus from Detroit to Tupelo, get comfy and count the stars.

          Buses are energy-efficient. Carrying a passenger over 100 kms by bus only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Detroit to Tupelo.

          Make a music playlist for your bus ride from Detroit to Tupelo, and enjoy the scenery to tunes from your own personal soundtrack.

          Did you know?

          One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

          It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

          The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

          Will you be returning to Detroit, MI by bus?

          Bus from Tupelo to Detroit, MI

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