Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Detroit Bus Station | Tupelo (Brothers Quick Stop) | Cheapest | ||||
| Bus | Detroit Bus Station | Tupelo (Brothers Quick Stop) | Fastest | ||||
| Bus | Detroit Bus Station | Tupelo (Brothers Quick Stop) | No tags | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Detroit Bus Station | Tupelo (Brothers Quick Stop) | No tags |
Last refresh of the prices: Last Tuesday at 11:09 PM EST.
Get from Detroit to Tupelo
The journey takes about 1 day, 40 minutes and with fares starting at just $133, it presents an excellent value for a comfortable ride.
Compare bus companies
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Frequently asked questions about traveling from Detroit, MI to Tupelo by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Detroit to Tupelo?
The cheapest bus tickets from Detroit to Tupelo start from $133. The average price for this route is around $166. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Detroit to Tupelo?
The average bus trip duration from Detroit to Tupelo is 1d , covering a distance of 636 miles (1025 km). The quickest bus can get you there in 19h 20m and is operated by Greyhound.
Which bus companies service the Detroit to Tupelo route?
Several major train operators operate on this route with 4 trains available per day.
What is the earliest and latest departure time for the bus from Detroit to Tupelo?
The earliest bus departs from Detroit to Tupelo at 6:40am. And the latest bus departs at 11:25pm.
What are the CO₂ emissions for the bus trip from Detroit to Tupelo?
A bus trip from Detroit to Tupelo generates an estimated 26 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Detroit, MI to Tupelo was searched and found on Dec 16, 2025 with a price of $181To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Detroit, MI to Tupelo, as early as possible.
You can expect to pay from $181 to $316 for a bus ticket from Detroit, MI to Tupelo based on the last 2 days. You can expect to find the cheapest price for the trip at $191 which is on 2025-12-20.
