Bus Tickets from Lafayette, LA to San Diego, CA, US
Next bus departures
Next departures for Lafayette to San Diego on November 24
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Lafayette Transit System
Greyhound Bus Stop
Cheapest
Bus
Lafayette Transit System
Greyhound Bus Stop
Fastest
Greyhound Lines, Inc. + FlixBus
Bus
Lafayette Transit System
San Diego (Old Town-FlixBus)
No tags
Bus
Lafayette Transit System
Greyhound Bus Stop
No tags
Greyhound Lines, Inc. + FlixBus
Bus
Lafayette Transit System
UCSD Health La Jolla Station
No tags
Last refresh of the prices: Yesterday at 6:19 PM CST.
Compare 2 ways to go from Lafayette to San Diego
We recommend taking the train
Among the sustainable travel choices, the train stands out as the good way to reach San Diego. The journey takes about 1 day, 23 hours 40 minutes and with fares starting at just $211, it presents an excellent value for a comfortable ride.
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.
Frequently asked questions about traveling from Lafayette, LA to San Diego, CA, US by bus
How far is Lafayette from San Diego?
About 1487 miles (2398 km) separate Lafayette and San Diego.
What are the departure and arrival stations when taking the bus from Lafayette to San Diego?
Most of the buses traveling from Lafayette to San Diego leave from TA Travel Center - Lafayette and arrive at Mission Valley Sheraton. These are the main pick-up and drop-off locations on this route, but you can also find other options that could better fit your plans.
What are the best sights and things to do in San Diego?
Once in San Diego, you can start exploring the city and discover its surroundings. The top sights and things to do are Balboa Park, Sunset Cliffs Natural Park, Boat Tours in San Diego, The Gaslamp Quarter and Botanical Building and Lily Pond.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
11/21
No data
11/22
$270
Today
No data
11/24
$335
11/25
No data
11/26
No data
11/27
No data
11/28
No data
The cheapest trip from Lafayette, LA to San Diego, CA, US was searched and found on Nov 22, 2025 with a price of $270
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Lafayette, LA to San Diego, CA, US, as early as possible.
You can expect to pay from $270 to $504 for a bus ticket from Lafayette, LA to San Diego, CA, US based on the last 2 days. You can expect to find the cheapest price for the trip at $335 which is on 2025-11-24.
What's the cheapest way to go from Lafayette, LA to San Diego, CA, US?
The bus is the cheapest travel choice for this destination
The cheapest trip from Lafayette, LA to San Diego, CA, US was searched and found on Nov 22, 2025 with a price of $270
The bus is the cheapest travel choice for this destination
