Next departures for Philadelphia to Charleston on November 22
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
FlixBus + Greyhound Lines, Inc.
Bus
Philadelphia, 199 Spring Garden St
4565 Gaynor Ave, North Charleston
CheapestFastest
Greyhound Lines, Inc. + FlixBus
Bus
199 Spring Garden St.
4565 Gaynor Ave, North Charleston
No tags
Bus
Schuylkill & Walnut
4565 Gaynor Ave, North Charleston
No tags
FlixBus + Greyhound Lines, Inc.
Bus
Cherry Hill Mall
4565 Gaynor Ave, North Charleston
No tags
Bus
Camden (Walter Rand Transportation Center)
4565 Gaynor Ave, North Charleston
No tags
Next departures for Philadelphia to Charleston on November 23
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Camden (Walter Rand Transportation Center)
4565 Gaynor Ave, North Charleston
Cheapest
FlixBus + Greyhound Lines, Inc.
Bus
Philadelphia, 199 Spring Garden St
4565 Gaynor Ave, North Charleston
Fastest
Greyhound Lines, Inc. + FlixBus
Bus
199 Spring Garden St.
4565 Gaynor Ave, North Charleston
No tags
Bus
Schuylkill & Walnut
4565 Gaynor Ave, North Charleston
No tags
FlixBus + Greyhound Lines, Inc.
Bus
Cherry Hill Mall
4565 Gaynor Ave, North Charleston
No tags
Next departures for Philadelphia to Charleston on November 24
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Greyhound Lines, Inc. + FlixBus
Bus
199 Spring Garden St.
4565 Gaynor Ave, North Charleston
Cheapest
FlixBus + Greyhound Lines, Inc.
Bus
Philadelphia, 199 Spring Garden St
4565 Gaynor Ave, North Charleston
Fastest
FlixBus + Greyhound Lines, Inc.
Bus
Cherry Hill Mall
4565 Gaynor Ave, North Charleston
No tags
Bus
Schuylkill & Walnut
4565 Gaynor Ave, North Charleston
No tags
FlixBus + Greyhound Lines, Inc.
Bus
Philadelphia (Logan Square)
4565 Gaynor Ave, North Charleston
No tags
Next departures for Philadelphia to Charleston on November 25
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Greyhound Lines, Inc. + FlixBus
Bus
199 Spring Garden St.
4565 Gaynor Ave, North Charleston
Cheapest
FlixBus + Greyhound Lines, Inc.
Bus
Philadelphia, 199 Spring Garden St
4565 Gaynor Ave, North Charleston
Fastest
FlixBus + Greyhound Lines, Inc.
Bus
Cherry Hill Mall
4565 Gaynor Ave, North Charleston
No tags
Bus
Schuylkill & Walnut
4565 Gaynor Ave, North Charleston
No tags
FlixBus + Greyhound Lines, Inc.
Bus
Frazer - 56-40 Matthews Rd
4565 Gaynor Ave, North Charleston
No tags
Next departures for Philadelphia to Charleston on November 26
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
FlixBus + Greyhound Lines, Inc.
Bus
Frazer - 56-40 Matthews Rd
4565 Gaynor Ave, North Charleston
Cheapest
FlixBus + Greyhound Lines, Inc.
Bus
Philadelphia, 199 Spring Garden St
4565 Gaynor Ave, North Charleston
Fastest
Greyhound Lines, Inc. + FlixBus
Bus
199 Spring Garden St.
4565 Gaynor Ave, North Charleston
No tags
Bus
Schuylkill & Walnut
4565 Gaynor Ave, North Charleston
No tags
FlixBus + Greyhound Lines, Inc.
Bus
Cherry Hill Mall
4565 Gaynor Ave, North Charleston
No tags
Next departures for Philadelphia to Charleston on November 27
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
FlixBus + Greyhound Lines, Inc.
Bus
Philadelphia, 199 Spring Garden St
4565 Gaynor Ave, North Charleston
CheapestFastest
Greyhound Lines, Inc. + FlixBus
Bus
199 Spring Garden St.
4565 Gaynor Ave, North Charleston
No tags
Bus
Schuylkill & Walnut
4565 Gaynor Ave, North Charleston
No tags
FlixBus + Greyhound Lines, Inc.
Bus
Cherry Hill Mall
4565 Gaynor Ave, North Charleston
No tags
Bus
Camden (Walter Rand Transportation Center)
4565 Gaynor Ave, North Charleston
No tags
Next departures for Philadelphia to Charleston on November 28
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
FlixBus + Greyhound Lines, Inc.
Bus
Frazer - 56-40 Matthews Rd
4565 Gaynor Ave, North Charleston
Cheapest
FlixBus + Greyhound Lines, Inc.
Bus
Philadelphia, 199 Spring Garden St
4565 Gaynor Ave, North Charleston
Fastest
Greyhound Lines, Inc. + FlixBus
Bus
199 Spring Garden St.
4565 Gaynor Ave, North Charleston
No tags
Bus
Schuylkill & Walnut
4565 Gaynor Ave, North Charleston
No tags
FlixBus + Greyhound Lines, Inc.
Bus
Cherry Hill Mall
4565 Gaynor Ave, North Charleston
No tags
Last refresh of the prices: Yesterday at 10:56 PM EST.
Compare 2 ways to go from Philadelphia to Charleston
We recommend taking the train
Among the sustainable travel choices, the train stands out as the good way to reach Charleston. The journey takes about 12 hours and with fares starting at just $93, it presents an excellent value for a comfortable ride.
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.
Frequently asked questions about traveling from Philadelphia, PA to Charleston, SC, US by bus
What is the distance between Philadelphia and Charleston?
About 562 miles (906 km) separate Philadelphia and Charleston.
What are the departure and arrival stations when taking the bus from Philadelphia to Charleston?
If you're headed to Charleston from Philadelphia, chances are that your bus will leave from Philadelphia Airport and arrive at Charleston Bus Station. These are the most popular departure and arrival locations on this route, but you can also find other options that could better fit your plans.
What are the best sights and things to do in Charleston?
Once in Charleston, you can start exploring the city and discover its surroundings. The top sights and things to do are Middleton Place, Fort Sumter, Dock Street Theatre, Theatre 99 and Charleston Ghost and Dungeon Tour.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
11/19
$142
11/20
$181
Today
$156
11/22
$162
11/23
$150
11/24
$187
11/25
$268
11/26
$216
The cheapest trip from Philadelphia, PA to Charleston, SC, US was searched and found on Nov 19, 2025 with a price of $142
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Philadelphia, PA to Charleston, SC, US, as early as possible.
You can expect to pay from $142 to $342 for a bus ticket from Philadelphia, PA to Charleston, SC, US based on the last 2 days. You can expect to find the cheapest price for the trip at $150 which is on 2025-11-23.
What's the cheapest way to go from Philadelphia, PA to Charleston, SC, US?
The bus is the cheapest travel choice for this destination