Bus Tickets from Portland, ME to St. Louis

Previously seen trips

Next departures for Portland to St. Louis on November 1
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Greyhound
    		Portland (Park & Ride)
    		Gateway StationNo tags
    Greyhound
      		Portland (Park & Ride)
      		Gateway StationNo tags
      Greyhound
        		Portland (Park & Ride)
        		Gateway StationNo tags
        Greyhound
          		Portland (Park & Ride)
          		Gateway StationNo tags
          Greyhound
            		Portland (Park & Ride)
            		Gateway StationNo tags

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            Compare 2 ways to go from Portland to St. Louis

            We recommend taking the bus

            Among the sustainable travel choices, the bus stands out as the good way to reach St. Louis. The journey takes about 1 day, 10 hours 40 minutes and with fares starting at just $265, it presents an excellent value for a comfortable ride.

            1bus per day
            1d 10hAverage Duration
            1090 milesDistance
            44kgCO₂ emissions
            Bus
            		Average Price$265 - $265Average Duration1d 10h
            44kg CO₂e
            Train
            		Average Price$371 - $371Average Duration1d 14h
            160kg CO₂e

            Bus Portland, ME to St. Louis: Trip Overview

            Average ticket price$265
            Average bus trip duration1d 10h
            Number of daily buses1
            Earliest bus departure1:45pm
            Distance1089 miles (1756 km)

            Portland to St. Louis Bus

            With Busbud, comparing and booking tickets for a bus from Portland to St. Louis is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

            We make it our job to connect you with the most dependable bus companies that cover bus service from Portland to St. Louis.

            From cheap bus tickets to more luxurious buses traveling from Portland to St. Louis, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

            Frequently asked questions for your trip Portland, ME - St. Louis

            Find cheapest prices for buses

            Price is for a one-way ticket for one passenger and based on past searches.

            Best price found
            10/30
            $257
            10/31
            No data
            Today
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            11/02
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            11/03
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            11/04
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            11/05
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            11/06
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            busbud logoThe cheapest trip from Portland, ME to St. Louis was searched and found on Oct 30, 2025 with a price of $257

            To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Portland, ME to St. Louis, as early as possible.

            About Bus Travel

            Bus Travel Tips

            Meet and talk to locals at the bus stations while traveling from Portland to St. Louis.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

            From miles long of beauteous natural landscapes to impressive man-crafted sights, you're bound to be in for a visual treat on your bus trip from Portland to St. Louis.

            Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Portland to St. Louis that are otherwise impossible to come by with a plane.

            Tune out to the fine sounds of your best music playlist on your bus trip from Portland to St. Louis while indulging in miles on end of beautiful scenic views.

            Did you know?

            One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

            Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

            The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.

            What's the cheapest way to go from Portland, ME to St. Louis?

            busbud logoThe bus is the cheapest travel choice for this destination

            Will you be returning to Portland, ME by bus?

            Bus from St. Louis to Portland, ME

            You can also go to St. Louis by train

            Train from Portland, ME to St. Louis

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            Popular Buses Connecting Portland

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            Popular Buses Connecting St. Louis

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