Previously seen trips
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Pueblo Lake Ave | Cross Border Xpress CBX (USA) | No tags | ||||
FlixBus + Greyhound | Bus | Pueblo Transit | San Diego (Old Town-FlixBus) | No tags | ||||
Greyhound + FlixBus | Bus | Pueblo Transit | Downtown SD (Seaport) | No tags | ||||
FlixBus + Greyhound | Bus | Pueblo Transit | UCSD Health La Jolla Station | No tags | ||||
 | Bus | Pueblo Transit | Greyhound Bus Stop | No tags |
Get from Pueblo to San Diego
This route is served by bus only
The journey takes about 1 day, 15 hours 10 minutes and with fares starting at just $161, it presents an excellent value for a comfortable ride.
13bus per day
1d 15hAverage Duration
797 milesDistance
32kgCO₂ emissions
Where are the popular stops in Pueblo and San Diego?
Stops in Pueblo
- A
Pueblo Transit Bus Station
123 Court St, Pueblo, CO 81003
Stops in San Diego
- A
Mission Valley Sheraton
1433 Camino del Rio S, San Diego, CA 92108, USA - B
Old Town Courtyard Marriot
2435 Jefferson St, San Diego, CA 92110, USA - C
Downtown Holiday Inn
1617 1st Ave, San Diego, CA 92101, USA - D
Greyhound Station
1313 National Ave, San Diego, CA 92101, USA - E
Market St. & Park Blvd
601 Park Boulevard, San Diego, CA 92101, USA - F
San Ysidro McDonald's
727 E San Ysidro Blvd, San Diego, CA 92173, USA
Compare bus companies
3.5 out of 5 stars3.5/587,386 reviews
3.5 out of 5 stars3.5/5266 reviews
US bus companies: FlixBus, BlaBlaCar Bus, ALSA, Greyhound, Intercape, Trenitalia, Sindbad
Frequently asked questions about traveling from Pueblo to San Diego, CA, US by bus
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
11/18
No data
11/19
No data
Today
No data
11/21
$224
11/22
No data
11/23
No data
11/24
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11/25
No data
The cheapest trip from Pueblo to San Diego, CA, US was searched and found on Nov 21, 2025 with a price of $224To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Pueblo to San Diego, CA, US, as early as possible.
You can expect to pay from $224 to $340 for a bus ticket from Pueblo to San Diego, CA, US based on the last 2 days. You can expect to find the cheapest price for the trip at $224 which is on 2025-11-21.
