Busbud recommends taking the bus from San Diego to San Luis Obispo
Among the sustainable travel choices, the bus stands out as the good way to reach San Luis Obispo. The journey takes about 8 hours 35 minutes and with fares starting at just $35, it presents an excellent value for a comfortable ride.
Based on 5418 reviews, the company was rated 4.1 stars on Busbud. Travelers were especially satisfied with the seats and the ticket access but often complained with the wifi. Amtrak ticket prices on this trip start at $65
Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Busbud helps you find a bus from San Diego to San Luis Obispo. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.
Bus service from San Diego to San Luis Obispo will be provided by the most trusted bus companies.
From cheap bus tickets to more luxurious buses traveling from San Diego to San Luis Obispo, we offer a wide range of bus services to best suit your needs depending on how much your budget is.
Where are the popular stops in San Diego and San Luis Obispo?
Frequently asked questions for your trip San Diego, CA, US - San Luis Obispo
What is the travel distance from San Diego to San Luis Obispo?
The distance between the two cities is 264 miles (426 km).
What are the departure and arrival stations when taking the bus from San Diego to San Luis Obispo?
The majority of buses traveling from San Diego to San Luis Obispo start their journey at Mission Valley Sheraton and wind up at AMTRAK Station. These are the primary departure and arrival locations on this route, there are other pick-up and drop-off locations that could make it easier for you to reach your destination.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
08/21
$84
08/22
$84
Today
$84
08/24
$84
08/25
$84
08/26
$84
08/27
$84
08/28
$84
The cheapest trip from San Diego, CA, US to San Luis Obispo was searched and found on Aug 21, 2025 with a price of $84
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Diego, CA, US to San Luis Obispo, as early as possible.
You can expect to pay from $84 to $84 for a bus ticket from San Diego, CA, US to San Luis Obispo based on the last 2 days. You can expect to find the cheapest price for the trip at $84 which is on 2025-08-24.
About Bus Travel
Bus Travel Tips
Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between San Diego and San Luis Obispo!
Much more than a mere vehicle taking you from San Diego to San Luis Obispo, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.
Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from San Diego to San Luis Obispo that are otherwise impossible to come by with a plane.
Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from San Diego to San Luis Obispo.
Did you know?
It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.
9.2% of ground transportation in Europe is done by bus versus 7.4% by train.
One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.
What's the cheapest way to go from San Diego, CA, US to San Luis Obispo?
The bus is the cheapest travel choice for this destination
Will you be returning to San Diego, CA, US by bus?
Busbud makes bus travel easy. We help travelers find a bus, plot routes, and book intercity bus tickets all over the world. Use Busbud to book your trip online, in your own language and currency, wherever you are. With Busbud, you can buy tickets with confidence. We ensure that you make the most out of your bus trip by partnering up with reliable bus companies from all around the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.