Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound Lines, Inc. + FlixBus | Bus | Santa Ana Bus Station | Chicago 95Th & Dan Ryan | Cheapest | ||||
FlixBus + Greyhound Lines, Inc. | Bus | Anaheim Regional Transportation Intermodal Center | Downtown Greyhound Station | Fastest | ||||
 | Bus | Anaheim Regional Transportation Intermodal Center | Downtown Greyhound Station | No tags | ||||
FlixBus + Greyhound Lines, Inc. | Bus | UC Irvine (Crawford Hall) | Downtown Greyhound Station | No tags | ||||
| Bus | Anaheim Regional Transportation Intermodal Center | 537-517 W. Jackson Blvd | No tags |
Last refresh of the prices: Last Tuesday at 5:19 PM PST.
Get from Santa Ana to Chicago
The journey takes about 2 days, 5 hours and with fares starting at just $224, it presents an excellent value for a comfortable ride.
Where are the popular stops in Santa Ana and Chicago?
Stops in Santa Ana
- A
Santa Ana Greyhound Bus Station
1000 E Santa Ana Blvd, Santa Ana, CA 92701 - B
602 S Main St
602 S Main St, Santa Ana, CA 92701, USA
Stops in Chicago
- A630 W Harrison St, Chicago, IL 60607, USA
- C
Polk St & Canal St
500-536 W Polk St, Chicago IL 60607, USA - D
Tornado Bus S Kedzie Ave
2807 S Kedzie Ave, Chicago, IL 60623, USA - E
Cumberland CTA
5800 N Cumberland Ave, Chicago, IL 60631, USA - F
Turimex California Ave
2139 S California Ave, Chicago, IL 60608, USA
Compare bus companies
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Greyhound Santa Ana Chicago recent customer reviews
I was suppose to arrive to Chicago Tuesday March 19 at 7:20am. I still haven’t arrived. My bus that picked me up to go to Las Vegas was late about 1:30-2:00 hours late. Had to wait about 10 hours for the next bus to leave to Denver which made me have to reschedule with a new bus.
Irma B.
Fast for a bus and clean little bit too crowded
Mariano V.
Frequently asked questions about traveling from Santa Ana, US to Chicago by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Santa Ana to Chicago?
The cheapest bus tickets from Santa Ana to Chicago start from $224. The average price for this route is around $345. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Santa Ana to Chicago?
The average bus trip duration from Santa Ana to Chicago is 2d 5h, covering a distance of 1728 miles (2786 km). The quickest bus can get you there in 2d 2h and is operated by Greyhound.
Which bus companies service the Santa Ana to Chicago route?
Several major train operators operate on this route with 14 trains available per day.
What is the earliest and latest departure time for the bus from Santa Ana to Chicago?
The earliest bus departs from Santa Ana to Chicago at 7:55am. And the latest bus departs at 9:40pm.
What are the CO₂ emissions for the bus trip from Santa Ana to Chicago?
A bus trip from Santa Ana to Chicago generates an estimated 70 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Santa Ana, US to Chicago was searched and found on Dec 6, 2025 with a price of $309To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Santa Ana, US to Chicago, as early as possible.
You can expect to pay from $309 to $400 for a bus ticket from Santa Ana, US to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at $328 which is on 2025-12-08.
