Bus Tickets from Santa Ana, US to San Diego, CA, US

Next departures

Next departures for Santa Ana to San Diego on November 1
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
FlixBus
    		Santa Ana Bus Station
    		UCSD Health La Jolla StationCheapestFastest
    Greyhound Lines, Inc.
      		Anaheim Regional Transportation Intermodal Center
      		Greyhound Bus StopNo tags
      FlixBus
        		Santa Ana Bus Station
        		San Diego (Old Town-FlixBus)No tags
        Los Limousines
          		Santa Ana E Santa Ana Blvd
          		Cross Border Xpress CBX (USA)No tags
          Greyhound Lines, Inc.
            		Anaheim Regional Transportation Intermodal Center
            		Greyhound Bus StopNo tags

            Last refresh of the prices: Today at 8:03 AM PDT.

            Accepted payments

            • Visa
            • MasterCard
            • American Express
            • China Union Pay
            • Diners Club Canada
            • Discover Click to Pay
            • JCB payment
            • Klarna (Pay over time)
            • Google Pay

            Get from Santa Ana to San Diego

            This route is served by bus only

            The journey takes about 2 hours 5 minutes and with fares starting at just $20, it presents an excellent value for a comfortable ride.

            25bus per day
            2h 5mAverage Duration
            98 milesDistance
            4kgCO₂ emissions

            Bus Santa Ana, US to San Diego, CA, US: Trip Overview

            Average ticket price$45
            Average bus trip duration2h 5m
            Number of daily buses25
            Earliest bus departure5:55am
            Distance98 miles (157 km)
            Latest bus departure10:45pm

            Santa Ana to San Diego Bus

            Busbud helps you find a bus from Santa Ana to San Diego. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

            We make sure you can find a bus service from Santa Ana to San Diego from the most reliable bus companies operating this trip.

            Whether it is cheap bus tickets or more luxurious buses going to San Diego from Santa Ana, we help you find what you're looking for based on how much of a budget you have.

            Frequently asked questions for your trip Santa Ana, US - San Diego, CA, US

            Find cheapest prices for buses

            Price is for a one-way ticket for one passenger and based on past searches.

            Best price found
            10/29
            $16
            10/30
            $16
            Today
            $19
            11/01
            $15
            11/02
            $15
            11/03
            $15
            11/04
            $14
            11/05
            $14
            busbud logoThe cheapest trip from Santa Ana, US to San Diego, CA, US was searched and found on Nov 4, 2025 with a price of $14

            To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Santa Ana, US to San Diego, CA, US, as early as possible.

            You can expect to pay from $14 to $44 for a bus ticket from Santa Ana, US to San Diego, CA, US based on the last 2 days. You can expect to find the cheapest price for the trip at $14 which is on 2025-11-04.

            Usually Los Limousines, Greyhound will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

            About Bus Travel

            Bus Travel Tips

            Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Santa Ana and San Diego!

            Start sightseeing the minute your bus leaves the station. If you're on the night bus from Santa Ana to San Diego, get comfy and count the stars.

            Buses are energy-efficient. Carrying a passenger over 100 kms by bus only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Santa Ana to San Diego.

            Make a music playlist for your bus ride from Santa Ana to San Diego, and enjoy the scenery to tunes from your own personal soundtrack.

            Did you know?

            The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.

            It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

            9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

            Will you be returning to Santa Ana, US by bus?

            Bus from San Diego, CA, US to Santa Ana, US

            Why choose Busbud?

            The Best Way To Book Bus and Train Tickets

            Busbud helps you easily search, compare and book intercity bus tickets on a worldwide scale with our comprehensive list of bus routes and schedules. With Busbud, wherever you go, you have a worldwide bus station within reach and available in your own language and currency. Busbud prides itself on its worldwide partnerships. We make it possible for you to buy tickets with its large network of trustworthy bus partners like Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

            People from around the world trust Busbud

            ‌

            Popular Buses Connecting Santa Ana

            Buses Leaving from Santa Ana

            Buses Going to Santa Ana

            Popular Buses Connecting San Diego

            Buses Leaving from San Diego

            Buses Going to San Diego