Bus Tickets from Wilmington, DE to St. Louis

Find affordable bus tickets from Wilmington, DE to St. Louis with flexible options. Book your trip now

Join 75M+ travelers booking 2M+ routes across 85+ countries.
Enjoy our 24/7 customer service to assist you at every step.
Cancel anytime and receive a 100% refund, no reason needed.

Previously seen trips

One passenger / one way

  • Departure time: August 24 at
    Departure city: Wilmington
    Departure location: Wilmington Bus Station
    Arrival time: August 25 at
    Destination city: St. Louis
    Destination location: Gateway Station
    Operated by: GreyhoundGreyhound
    Vehicle: BusDuration:
  • Departure time: August 24 at
    Departure city: Wilmington
    Departure location: Newark (DE)
    Arrival time: August 25 at
    Destination city: St. Louis
    Destination location: Gateway Station
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:
  • Departure time: August 24 at
    Departure city: Wilmington
    Departure location: Delaware Rest Stop S
    Arrival time: August 25 at
    Destination city: St. Louis
    Destination location: Gateway Station
    Operated by: Greyhound + FlixBus
    Greyhound + FlixBus
    Vehicle: BusDuration:
  • Departure time: August 24 at
    Departure city: Wilmington
    Departure location: Newark (DE)
    Arrival time: August 25 at
    Destination city: St. Louis
    Destination location: Gateway Station
    Operated by: Greyhound + FlixBus
    Greyhound + FlixBus
    Vehicle: BusDuration:
  • Departure time: August 24 at
    Departure city: Wilmington
    Departure location: Wilmington Bus Station
    Arrival time: August 25 at
    Destination city: St. Louis
    Destination location: Gateway Station
    Operated by: GreyhoundGreyhound
    Vehicle: BusDuration:

Accepted payments

  • Visa
  • MasterCard
  • American Express
  • China Union Pay
  • Diners Club Canada
  • Discover Click to Pay
  • JCB payment
  • Klarna (Pay over time)
  • Google Pay

Compare 2 ways to go from Wilmington to St. Louis.

Bus
Average Price$96 - $211Average Duration1d 3h
31kg CO₂e5 out of 5 stars
CheapestFastestMost eco-friendly
Train
Average Price$193 - $442Average Duration1d 11h
115kg CO₂e1 out of 5 stars
busbud logoBusbud recommends taking the bus from Wilmington to St. Louis

Among the sustainable travel choices, the bus stands out as the good way to reach St. Louis. The journey takes about 1 day, 3 hours 55 minutes and with fares starting at just $96, it presents an excellent value for a comfortable ride.

7bus per day
1d 3hAverage Duration
$96Cheapest ticket
31kgCO₂ emissions

Bus Wilmington, DE to St. Louis: Trip Overview

Average ticket price$139
Average bus trip duration1d 3h
Number of daily buses7
Earliest bus departure2:50am
Distance779 miles (1255 km)
Latest bus departure9:25pm

Wilmington to St. Louis Bus

Busbud helps you find a bus from Wilmington to St. Louis. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

Bus service from Wilmington to St. Louis will be provided by the most trusted bus companies.

Whether it is cheap bus tickets or more luxurious buses going to St. Louis from Wilmington, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions for your trip Wilmington, DE - St. Louis

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
08/23
No data
08/24
$105
Today
No data
08/26
No data
08/27
No data
08/28
No data
08/29
No data
08/30
No data
busbud logoThe cheapest trip from Wilmington, DE to St. Louis was searched and found on Aug 24, 2025 with a price of $105

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Wilmington, DE to St. Louis, as early as possible.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Wilmington and St. Louis!

Much more than a mere vehicle taking you from Wilmington to St. Louis, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Wilmington to St. Louis.

Tune out to the fine sounds of your best music playlist on your bus trip from Wilmington to St. Louis while indulging in miles on end of beautiful scenic views.

Did you know?

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travelers have used their electronic device on board during 2014.

The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

What's the cheapest way to go from Wilmington, DE to St. Louis?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to Wilmington, DE by bus?

Bus from St. Louis to Wilmington, DE

You can also go to St. Louis by train

Train from Wilmington, DE to St. Louis

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud helps you easily search, compare and book intercity bus tickets on a worldwide scale with our comprehensive list of bus routes and schedules. With Busbud, wherever you go, you have a worldwide bus station within reach and available in your own language and currency. Busbud partners with safe and reliable bus companies throughout the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others so you can buy tickets without a worry.

People from around the world trust Busbud

‌

Popular Buses Connecting Wilmington

Buses Leaving from Wilmington

Buses Going to Wilmington

Popular Buses Connecting St. Louis

Buses Leaving from St. Louis

Buses Going to St. Louis