Previously seen trips
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
FlixBus + Greyhound | Bus | Lake City Bus Station | Downtown Greyhound Station | No tags | ||||
 | Bus | Lake City Bus Station | 537-517 W. Jackson Blvd | No tags | ||||
FlixBus + Greyhound | Bus | Lake City Bus Station | Chicago 95Th & Dan Ryan | No tags | ||||
FlixBus + Greyhound | Bus | Lake City Bus Station | Downtown Greyhound Station | No tags | ||||
FlixBus + Greyhound | Bus | Lake City Bus Station | 537-517 W. Jackson Blvd | No tags |
Get from Lake City to Chicago
The journey takes about 1 day, 1 hour 15 minutes, and with fares starting at just $164, it presents an excellent value for a comfortable ride.
Where are the popular stops in Lake City and Chicago?
Stops in Lake City
- A2470 W US HWY 90, Lake City, FL 32025, USA
- B
Lake City Greyhound Bus Station
251 S MARION AVE , 32055, Florida
Stops in Chicago
- A630 W Harrison St, Chicago, IL 60607, USA
- C
Polk St & Canal St
500-536 W Polk St, Chicago IL 60607, USA - D
Tornado Bus S Kedzie Ave
2807 S Kedzie Ave, Chicago, IL 60623, USA - E
Cumberland CTA
5800 N Cumberland Ave, Chicago, IL 60631, USA - F
Turimex California Ave
2139 S California Ave, Chicago, IL 60608, USA
Compare bus companies
Frequently asked questions about travelling from Lake City to Chicago by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Lake City to Chicago?
The cheapest bus tickets from Lake City to Chicago start from $164. The average price for this route is around $205. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Lake City to Chicago?
The average bus travel time from Lake City to Chicago is 1d 1h, covering a distance of 1359 km. The quickest bus can get you there in 22h 35m and is operated by FlixBus.
Which bus companies service the Lake City to Chicago route?
What are the earliest and latest departure times for the bus from Lake City to Chicago?
The earliest bus departs from Lake City to Chicago at 9:35am. And the latest bus departs at 7:30pm.
What are the CO₂ emissions for the bus trip from Lake City to Chicago?
A bus trip from Lake City to Chicago generates an estimated 34 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
What is the best bus company from Lake City to Chicago?
According to Busbud customers, the highest-rated bus company on this route is Greyhound, with an average rating of 3.5 out of 5 stars based on 87412 reviews.
Which bus company has the best Wi-Fi from Lake City to Chicago?
Based on Busbud reviews, the bus company FlixBus has the highest Wi-Fi rating with a score of 2.7.
Which bus company has the best on-time performance from Lake City to Chicago?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Lake City to Chicago?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Lake City to Chicago was searched and found on Dec 7, 2025 with a price of $169To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Lake City to Chicago, as early as possible.
