Bus Tickets from Lake City to Panama City, US

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Bus Lake City to Panama City: Trip Overview

Average Ticket PriceUS$42
Average Bus Trip Duration5h
Number of daily buses1
Earliest bus departure9:40am
Distance301 km

Lake City to Panama City Bus

Busbud helps you find a bus from Lake City to Panama City. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

We make sure you can find a bus service from Lake City to Panama City from the most reliable bus companies operating this trip.

From cheap bus tickets to more luxurious buses travelling from Lake City to Panama City, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions on the trip Lake City - Panama City, US

  1. How long is the trip from Lake City to Panama City by bus?

    The typical travel time from Lake City to Panama City by bus is around 5h. If you're looking for the fastest way to get there, you'll find a bus doing the trip in about 5h.

  2. What is the travel distance from Lake City to Panama City?

    The distance between Lake City and Panama City is around 293 km (182 miles).

  3. What are the departure and arrival locations for buses traveling from Lake City to Panama City?

    Buses traveling this route start their trip at Lake City Bus Stop, in Lake City, and end it at Panama City Greyhound Bus Station, in Panama City.

  4. What is the cheapest way to go from Lake City to Panama City?

    If you're on a budget, consider traveling by bus to Panama City from Lake City; it tends to be more affordable. Starting at US$42, this bus is the most cost-effective option for your journey.

  5. How much does the bus ticket cost from Lake City to Panama City?

    Taking the bus from Lake City to Panama City costs on average US$42.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
05-27
US$74
05-28
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busbud logoThe cheapest trip from Lake City to Panama City was searched and found on May 27, 2025 with a price of US$74

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Lake City to Panama City, as early as possible.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Lake City and Panama City!

Start sightseeing the minute your bus leaves the station. If you're on the night bus from Lake City to Panama City, get comfy and count the stars.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Lake City to Panama City that are otherwise impossible to come by with a plane.

Tune out to the fine sounds of your best music playlist on your bus trip from Lake City to Panama City while indulging in miles on end of beautiful scenic views.

Did you know?

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travellers have used their electronic device on board during 2014.

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

Will you be returning to Lake City by bus?

Bus from Lake City to Panama City

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