Next departures for Detroit to St. Louis on November 24
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Detroit Bus Station
Gateway Station
CheapestFastest
Next departures for Detroit to St. Louis on November 25
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Greyhound Lines, Inc. + FlixBus
Bus
Detroit Bus Station
Gateway Station
Cheapest
Greyhound Lines, Inc. + FlixBus
Bus
Detroit Bus Station
Gateway Station
Fastest
Bus
Detroit Bus Station
Gateway Station
No tags
Next departures for Detroit to St. Louis on November 26
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Detroit Bus Station
Gateway Station
Cheapest
Greyhound Lines, Inc. + FlixBus
Bus
Detroit Bus Station
Gateway Station
Fastest
Bus
Detroit Bus Station
Gateway Station
No tags
Next departures for Detroit to St. Louis on November 27
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Detroit Bus Station
Gateway Station
Cheapest
Greyhound Lines, Inc. + FlixBus
Bus
Detroit Bus Station
Gateway Station
Fastest
Bus
Detroit Bus Station
Gateway Station
No tags
Next departures for Detroit to St. Louis on November 28
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Greyhound Lines, Inc. + FlixBus
Bus
Detroit Bus Station
Gateway Station
Cheapest
Greyhound Lines, Inc. + FlixBus
Bus
Detroit Bus Station
Gateway Station
Fastest
Bus
Detroit Bus Station
Gateway Station
No tags
Next departures for Detroit to St. Louis on November 29
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Greyhound Lines, Inc. + FlixBus
Bus
Detroit Bus Station
Gateway Station
Cheapest
Greyhound Lines, Inc. + FlixBus
Bus
Detroit Bus Station
Gateway Station
Fastest
Bus
Detroit Bus Station
Gateway Station
No tags
Last refresh of the prices: Yesterday at 5:36 PM EST.
Compare 2 ways to go from Detroit to St. Louis
We recommend taking the train
Among the sustainable travel choices, the train stands out as the good way to reach St. Louis. The journey takes about 13 hours 41 minutes and with fares starting at just $75, it presents an excellent value for a comfortable ride.
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.
Frequently asked questions about traveling from Detroit, MI to St. Louis by bus
What is the distance between Detroit and St. Louis?
About 454 miles (733 km) separate Detroit and St. Louis.
What are the departure and arrival stations when taking the bus from Detroit to St. Louis?
Buses traveling from Detroit to St. Louis leave from Detroit Bus Station and arrive at Gateway Station.
What are the best sights and things to do in St. Louis?
Once in St. Louis, you can start exploring the city and discover its surroundings. The top sights and things to do are Powell Symphony Hall, Lumière Place, Missouri Botanical Garden, Forest Park and Saint Louis Zoo.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
11/22
$138
11/23
$153
Today
$182
11/25
$289
11/26
$138
11/27
$84
11/28
$108
11/29
$203
The cheapest trip from Detroit, MI to St. Louis was searched and found on Nov 27, 2025 with a price of $84
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Detroit, MI to St. Louis, as early as possible.
You can expect to pay from $84 to $289 for a bus ticket from Detroit, MI to St. Louis based on the last 2 days. You can expect to find the cheapest price for the trip at $84 which is on 2025-11-27.
What's the cheapest way to go from Detroit, MI to St. Louis?
The bus is the cheapest travel choice for this destination