Bus Tickets from Detroit, MI to St. Louis

Next bus departures

Next departures for Detroit to St. Louis on November 25
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Greyhound Lines, Inc. + FlixBus
Bus
Detroit Bus Station
Gateway StationCheapest
Greyhound Lines, Inc. + FlixBus
Bus
Detroit Bus Station
Gateway StationFastest
Greyhound Lines, Inc.Bus
Detroit Bus Station
Gateway StationNo tags

Last refresh of the prices: Yesterday at 5:36 PM EST.

Compare 2 ways to go from Detroit to St. Louis

We recommend taking the train

Among the sustainable travel choices, the train stands out as the good way to reach St. Louis. The journey takes about 13 hours 41 minutes and with fares starting at just $75, it presents an excellent value for a comfortable ride.

1train per day
13h 41mAverage Duration
455 milesDistance
67kgCO₂ emissions
Average Price$71 - $240Average Duration15h 50m
18kg CO₂e
Average Price$75 - $474Average Duration13h 41m
67kg CO₂e

Frequently asked questions about traveling from Detroit, MI to St. Louis by bus

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
11/22
$138
11/23
$153
Today
$182
11/25
$289
11/26
$138
11/27
$84
11/28
$108
11/29
$203
busbud logoThe cheapest trip from Detroit, MI to St. Louis was searched and found on Nov 27, 2025 with a price of $84

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Detroit, MI to St. Louis, as early as possible.

You can expect to pay from $84 to $289 for a bus ticket from Detroit, MI to St. Louis based on the last 2 days. You can expect to find the cheapest price for the trip at $84 which is on 2025-11-27.

What's the cheapest way to go from Detroit, MI to St. Louis?

busbud logoThe bus is the cheapest travel choice for this destination

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